Introduction: Amyloid β (Aβ) is a brain protein that causes Alzheimer's disease (AD). This study aimed to verify whether hemadsorption using a hexadecyl-alkylated cellulose bead (HexDC) column removes blood Aβ and brain Aβ accumulation in mild cognitive impairment/mild AD cases with normal kidney function.
Methods: Two patients with positive Aβ on brain imaging underwent HexDC hemadsorption weekly for 6 months.
Results: The Aβ removal efficiency of HexDC was 87-99%. Aβ /Aβ influx into the blood in one session was 596/56 and 489/48 ng for Case A and Case B, respectively. Although brain Aβ accumulation did not clearly change after 6 months of hemadsorption, cognitive functions measured by the two tests were maintained or slightly improved.
Conclusion: Blood Aβ removal was performed in two early AD patients with normal kidney function without adverse events, and it slightly improved or maintained cognitive function.
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| http://dx.doi.org/10.1111/1744-9987.13827 | DOI Listing |
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