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Background: Radiotherapy has become much better targeted since the 1980s, improving both safety and efficacy. In breast cancer, radiotherapy to regional lymph nodes aims to reduce risks of recurrence and death. Its effects have been studied in randomised trials, some before the 1980s and some after.
View Article and Find Full Text PDFBackground: Anthracycline-taxane chemotherapy for early-stage breast cancer substantially improves survival compared with no chemotherapy. However, concerns about short-term and long-term side-effects of anthracyclines have led to increased use of taxane chemotherapy without anthracycline, which could compromise efficacy. We aimed to better characterise the benefits and risks of including anthracycline, and the comparative benefits of different anthracycline-taxane regimens.
View Article and Find Full Text PDFNationally Informed Recommendations on Approaching the Detection, Assessment, and Management of Mild Cognitive Impairment.
J Alzheimers Dis
October 2022
Grampians Health, Deakin University, Victoria, Australia.
Prior to the usual clinical symptoms of dementia, there can be subtle changes in cognitive function that differ from the normal age-related cognitive decline, which has been termed mild cognitive impairment (MCI). The increase in the numbers of individuals with possible MCI presenting to health care professionals, notably, General Practitioners (GPs), is going to rise dramatically in the coming years. With ever increasing demands on GPs, it is therefore timely to provide information that can be accessed by health care professionals to assist them in making appropriate diagnoses and to provide the most relevant, evidence-based treatment options.
View Article and Find Full Text PDFThe biomechanical significance of the elongated rodent incisor root in the mandible during incision.
Sci Rep
March 2022
Hull York Medical School and Department of Archaeology, University of York, York, YO10 5DD, UK.
Rodents are characterised by a distinctive masticatory apparatus which includes a single pair of enlarged and continually growing incisors. This morphology, termed diprotodonty, has also independently evolved in a number of other mammals, including the aye-aye. This study examined the functional significance of the internal "root" of the elongated rodent-like incisor.
View Article and Find Full Text PDFIntroduction to the special issue on supersonic jet noise.
J Acoust Soc Am
February 2022
Advanced Propulsion and Power Laboratory, Virginia Tech, Blacksburg, Virginia 24061, USA.
This editorial's goals are (1) to highlight a few key developments in supersonic jet and launch vehicle noise research over the past several decades while describing some of the critical modern requirements facing government and industry organizations and (2) to summarize the contributions of the articles in this Supersonic Jet Noise special issue in the context of these developments and requirements.
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