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| http://dx.doi.org/10.4269/ajtmh.22-0003 | DOI Listing |
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Novel isothermal nucleic acid amplification method for detecting malaria parasites.
Appl Microbiol Biotechnol
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Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Malaria, a parasitic disease caused by Plasmodium spp. and transmitted by Anopheles mosquitoes, remains a major global health issue, with an estimated 249 million cases and 608,000 deaths in 2022. Rapid and accurate diagnosis and treatment are crucial for malaria control and elimination.
View Article and Find Full Text PDFFirst Report of Rhodnius stali Lent, Jurberg, and Galvão 1993 (Hemiptera: Reduviidae: Triatominae) Naturally Infected by Trypanosoma cruzi in Concepción Department, Paraguay.
Am J Trop Med Hyg
December 2024
Centro para el Desarrollo de la Investigación Científica, Asunción, Paraguay.
Most triatomine bugs inhabit nests and shelters of vertebrates, some of which are closely associated with palm trees. A few species occupy domestic and peridomestic habitats, posing a threat to human health as natural transmitters of Chagas disease. A peridomestic specimen that yielded positive results for Trypanosoma cruzi in both microscope and polymerase chain reaction tests was collected during a vector control survey in northeastern Paraguay.
View Article and Find Full Text PDFEvaluation of the Vitros® Anti-T. cruzi assay for its incorporation into the infection diagnostic algorithm.
Heliyon
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Microbiology Department, Clinical Laboratory North Metropolitan Area, Germans Trias I Pujol University Hospital, 08916 Badalona, Spain.
Background And Objective: Serological screening for Chagas disease (CD) in Latin American adults living in Europe is a cost-effective strategy for transmission prevention. The World Health Organization recommends two different serological tests including native and recombinant antigens for IgG detection. In Spain, most commercialized native tests require manual processing.
View Article and Find Full Text PDFExperimental crosses detect reproductive isolation among populations of Triatoma pallidipennis (Hemiptera: Reduviidae: Triatominae).
J Med Entomol
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Laboratorio de Entomología Médica, Departamento de Ciencias de la Naturaleza, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Jalisco, México.
Chagas disease is one of the most important vector-borne diseases in Mexico. Triatoma pallidipennis (Stål) is one of the most epidemiologically important vector species. Despite being classified as a single species, various studies (molecular, morphometric, and biological) on populations across its distribution suggested it is composed of a group of cryptic species.
View Article and Find Full Text PDFWnt/β-catenin pathway as a link between therapy resistance-driven epithelial-mesenchymal transition and stemness in colorectal cancer.
Cell Biol Int
December 2024
Cellular and Molecular Oncobiology Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
The high plasticity of cells undergoing epithelial-mesenchymal transition (EMT) promotes increased tumor heterogeneity, and its interaction with tumor-associated stromal cells appears to contribute to developing a stemness phenotype. Cells with these characteristics exhibit increased resistance to chemotherapy and radiotherapy, leading to disease relapse and metastasis. Here, we discuss the activation of the Wnt/β-catenin pathway in promoting EMT and stemness within the context of cellular resistance to these therapies.
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