AI Article Synopsis
- The study investigates the relationship between serum levels of sCD95 and TNF-α and their effect on apoptosis in Jurkat cells, aiming to develop a non-invasive diagnostic method for cervical cancer (CC).
- Results indicated that cervical cancer patients had higher sCD95 and lower TNF-α levels, which reduced apoptosis in Jurkat cells by affecting JNK phosphorylation.
- The findings suggest that monitoring these serum levels could provide a valuable approach for early detection of cervical cancer.
Article Abstract
Background: This study correlates the serum levels of sCD95 & TNF-α with a simple cell-based assay to evaluate the capacity of the serum sample to induce apoptosis in Jurkat cells. Interlinking of these parameters can be explored to design a minimum invasive diagnostic strategy for cervical cancer (CC).
Methods: Sera samples were assessed to induce apoptosis in Jurkat cells through FACS. Serum levels of sCD95 and TNF-α were measured by ELISA. JNK phosphorylation was evaluated in sera incubated Jurkat cells. Data was scrutinized through statistical analysis.
Results: Significantly higher serum levels of sCD95 and lower TNF-α levels were observed in CC patients; their sera samples inhibited induction of apoptosis in Jurkat cells through reduced JNK phosphorylation. Statistical analysis linked these three parameters for the early screening of CC.
Conclusion: Distinct sera levels of sCD95 & TNF-α in CC patients showed an anti-apoptotic effect, which can be considered for early detection of CC.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903371 | PMC |
| http://dx.doi.org/10.52547/rbmb.10.4.711 | DOI Listing |
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