AI Article Synopsis
- * The study demonstrates that these NDs can be coated with a polypeptide biopolymer to enhance cellular uptake, enabling live-cell dual-color imaging and intracellular tracking for the first time.
- * Additionally, the research explores using SiV-NDs for intracellular thermometry and discusses challenges related to atomic defects, highlighting their potential in diagnostics and drug delivery.
Article Abstract
Nanodiamonds (NDs) with color centers are excellent emitters for various bioimaging and quantum biosensing applications. In our work, we explore new applications of NDs with silicon-vacancy centers (SiV) obtained by high-pressure high-temperature (HPHT) synthesis based on metal-catalyst-free growth. They are coated with a polypeptide biopolymer, which is essential for efficient cellular uptake. The unique optical properties of NDs with SiV are their high photostability and narrow emission in the near-infrared region. Our results demonstrate for the first time that NDs with SiV allow live-cell dual-color imaging and intracellular tracking. Also, intracellular thermometry and challenges associated with SiV atomic defects in NDs are investigated and discussed for the first time. NDs with SiV nanoemitters provide new avenues for live-cell bioimaging, diagnostic (SiV as a nanosized thermometer), and theranostic (nanodiamonds as drug carrier) applications.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011402 | PMC |
| http://dx.doi.org/10.1021/acs.nanolett.2c00040 | DOI Listing |
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