AI Article Synopsis
- Magnetic resonance elastography (MRE) is a noninvasive imaging technique used to assess the shear properties of the intervertebral disc (IVD), and the study compares a new spin-echo echo-planar imaging (SE-EPI) method against the standard gradient recalled echo (GRE) method.
- A cross-over study involving 28 healthy volunteers evaluated the performance of SE-EPI, showing good correlation in shear stiffness measurements with GRE and demonstrating that SE-EPI provides more efficient imaging with up to a 51% reduction in scan time.
- Results indicated that SE-EPI produced highly reproducible stiffness measurements, supporting its potential as a superior alternative to GRE for evaluating IVD properties.
Article Abstract
Background: Magnetic resonance elastography (MRE) is an imaging technique that can noninvasively assess the shear properties of the intervertebral disc (IVD). Unlike the standard gradient recalled echo (GRE) MRE technique, a spin-echo echo-planar imaging (SE-EPI) sequence has the potential to improve imaging efficiency and patient compliance.
Purpose: To validate the use of an SE-EPI sequence for MRE of the IVD compared against the standard GRE sequence.
Study Type: Cross-over.
Subjects: Twenty-eight healthy volunteers (15 males and 13 females, age range: 19-55).
Field Strength/sequence: 3 T; GRE, SE-EPI with breath holds (SE-EPI-BH) and SE-EPI with free breathing (SE-EPI-FB) MRE sequences.
Assessment: MRE-derived shear stiffnesses were calculated via principal frequency analysis. SE-EPI derived shear stiffness and octahedral shear strain signal-to-noise ratios (OSS-SNR) were compared against those derived using the GRE sequence. The reproducibility and repeatability of SE-EPI stiffness measurements were determined. Shear stiffness was evaluated in the nucleus pulposus (NP) and annulus fibrosus (AF) regions of the disc. Scan times between sequences were compared.
Statistical Tests: Linear mixed models, Bland-Altman plots, and Lin's concordance correlation coefficients (CCCs) were used with P < 0.05 considered statistically significant.
Results: Good correlation was observed between shear stiffnesses derived from the SE-EPI sequences with those derived from the GRE sequence with CCC values greater than 0.73 and 0.78 for the NP and AF regions, respectively. OSS-SNR was not significantly different between GRE and SE-EPI sequences (P > 0.05). SE-EPI sequences generated highly reproducible and repeatable stiffness measurements with CCC values greater than 0.97 in the NP and AF regions and reduced scan time by at least 51% compared to GRE. SE-EPI-BH and SE-EPI-FB stiffness measurements were similar with CCC values greater than 0.98 for both regions.
Data Conclusion: SE-EPI-based MRE-derived stiffnesses were highly reproducible and repeatable and correlated with current standard GRE MRE-derived stiffness estimates while reducing scan times.
Level Of Evidence: 1 TECHNICAL EFFICACY STAGE: 1.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9475395 | PMC |
| http://dx.doi.org/10.1002/jmri.28151 | DOI Listing |
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