A synthesis of azepines by the expansion of pyridine rings promoted by iodine in air is reported. The scope of the method is demonstrated with 27 examples. Two iodinations are involved in the reaction, in which the second iodination leads to the opening of the six-membered ring.
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| http://dx.doi.org/10.1021/acs.orglett.2c00130 | DOI Listing |
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