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Insecticidal efficacy of afoxolaner against (Diptera: Muscidae) in dogs. | LitMetric

Insecticidal efficacy of afoxolaner against (Diptera: Muscidae) in dogs.

Curr Res Parasitol Vector Borne Dis

Boehringer Ingelheim Animal Health, 29 Avenue Tony Garnier, 69007 Lyon, France.

Published: July 2021

AI Article Synopsis

Article Abstract

The insecticidal activity of oral afoxolaner (NexGard®) against stable flies (Diptera: Muscidae) that had fed on dogs was evaluated in a blinded, randomised, and negative controlled efficacy study. The efficacy assessments were based on survival rates of fed flies after challenges to treated dogs. For a challenge, each dog was exposed to 50 unfed for 30 minutes, after which time live fed flies were collected and incubated in an insectarium for viability assessment after 48, 72 and 96 hours. Fourteen dogs were randomly allocated to an untreated control group and an afoxolaner-treated group of seven dogs each. NexGard® was administered on Day 0 per label instructions to the treated group. All dogs were challenged on Days 1, 7, 14, 21 and 28. Efficacy was calculated by comparison of the proportion of incubated live fed flies for each individual after their related 30-min challenges in the control and treated groups after 48, 72 and 96 hours of incubation. A significant afoxolaner activity against was demonstrated, with efficacy at 96 hours after blood-feeding ranging from 76.4 to 98.5% through Day 28.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906105PMC
http://dx.doi.org/10.1016/j.crpvbd.2021.100043DOI Listing

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