AI Article Synopsis
- Recurrence poses a significant risk to the postoperative survival of patients with hepatocellular carcinoma (HCC), particularly those with elevated preoperative serum γ-glutamyl transpeptidase (GGT) levels.
- This study aimed to create a predictive tool to assess the risk of recurrence in patients with HBV-related HCC and high GGT levels following liver surgery.
- A nomogram was developed using five key prognostic factors, achieving a C-index of 0.759, demonstrating reliability in predicting recurrence and aiding in personalized treatment strategies.
Article Abstract
Background: Recurrence is a major risk factor affecting the postoperative survival of patients with hepatocellular carcinoma (HCC), especially those with high preoperative serum γ-glutamyl transpeptidase (GGT) levels. This study had the aim of developing a personalized predictive tool to accurately determine the risk of postoperative recurrence of hepatitis B-virus (HBV)-related HCC in patients with high preoperative serum GGT levels.
Methods: Patients who underwent curative liver resection of HBV-related HCC and had high preoperative GGT levels were consecutively enrolled between 2008 and 2011. Prognostic indicators for recurrence were determined using Cox regression analysis. A nomogram was then developed and assessed by integrating the independent risk factors into the model.
Results: A total of 603 eligible patients were included. The final nomogram for predicting HCC recurrence in patients with high preoperative GGT levels consisted of five independent prognostic factors: α-fetoprotein (AFP), HBV-DNA, satellite nodules, microvascular invasion, and tumor grade. The C-index of the nomogram for predicting recurrence was 0.759, and validation showed high accuracy and discriminatory.
Conclusions: The predictive nomogram developed and validated in this study performs well in predicting postoperative recurrence of HBV-related HCC in patients with high preoperative GGT levels. It can provide personalized assessments to inform the development of surveillance strategies and allows patients with a high risk of recurrence to be selected for further adjuvant treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899756 | PMC |
| http://dx.doi.org/10.21037/jgo-21-450 | DOI Listing |
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