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Weighing in on Adipogenesis. | LitMetric

Weighing in on Adipogenesis.

Front Physiol

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States.

Published: February 2022

AI Article Synopsis

  • Obesity is a major global health issue linked to serious conditions like metabolic syndrome, type II diabetes, insulin resistance, and various cancers.
  • It involves two main processes in the expansion of white adipose tissue: hyperplasia (increase in fat cell number) and hypertrophy (increase in fat cell size), with hypertrophy being more harmful to metabolic health.
  • Understanding how adipogenesis is regulated can lead to new therapies aimed at combating obesity and its related health problems.

Article Abstract

Obesity is a growing health concern worldwide because of its contribution to metabolic syndrome, type II diabetes, insulin resistance (IR), and numerous cancers. In obesity, white adipose tissue (WAT) expands through two mechanisms: increase in adipocyte cell number by precursor cell differentiation through the process of adipogenesis (hyperplasia) and increase in existing mature adipocyte cell size (hypertrophy). While hypertrophy is associated with the negative effects of obesity on metabolic health, such as inflammation and lipotoxicity, adipogenesis prevents obesity-mediated metabolic decline. Moreover, in metabolically healthy obesity adipogenesis is increased. Thus, it is vital to understand the mechanistic basis for adipose expansion to inform novel therapeutic approaches to mitigate the dysfunction of this tissue and associated diseases. In this mini-review, we summarize recent studies on the regulation of adipogenesis and provide a perspective on targeting adipogenesis as a potential therapeutic avenue for metabolic disorders.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914022PMC
http://dx.doi.org/10.3389/fphys.2022.821278DOI Listing

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