AI Article Synopsis
- COVID-19, caused by SARS-CoV-2, is linked to acute myocardial infarction (AMI), but the exact mechanisms connecting the two conditions are not well understood.
- The study used bioinformatics to analyze gene expression in peripheral blood mononuclear cells from patients with both AMI and COVID-19, identifying differentially expressed genes and exploring their functions.
- Findings from the analysis highlight the potential biological connections and roles of specific genes in the pathophysiology of COVID-19-related AMI.
Article Abstract
Introduction: Accumulating evidences disclose that COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a marked effect on acute myocardial infarction (AMI). Nevertheless, the underlying pathophysiology correlation between the AMI and COVID-19 remains vague.
Materials And Methods: Bioinformatics analyses of the altered transcriptional profiling of peripheral blood mononuclear cells (PBMCs) in patients with AMI and COVID-19 were implemented, including identification of differentially expressed genes and common genes between AMI and COVID-19, protein-protein interactions, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses, TF-genes and miRNA coregulatory networks, to explore their biological functions and potential roles in the pathogenesis of COVID-19-related AMI.
Conclusion: Our bioinformatic analyses of gene expression profiling of PBMCs in patients with AMI and COVID-19 provide us with a unique view regarding underlying pathophysiology correlation between the two vital diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8904943 | PMC |
| http://dx.doi.org/10.2147/IJGM.S354885 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!