AI Article Synopsis
- The study investigated how different concentrations of a chemical stimulant (K) affect synaptic plasticity, specifically focusing on the release of catecholamines from single cells.
- It was found that at lower concentrations (10 mM K), there were no changes in catecholamine release, while higher concentrations (30 and 50 mM K) led to increased release, and very high concentration (100 mM K) resulted in decreased release.
- These findings suggest that the concentration of the stimulant can regulate molecular changes that influence exocytotic plasticity, linking stimulation intensity with potential synaptic changes.
Article Abstract
Activity-induced synaptic plasticity has been intensively studied, but is not yet well understood. We examined the temporal and concentration effects of exocytotic molecular plasticity during and immediately after chemical stimulation (30 s K stimulation) single cell amperometry. Here the first and the second 15 s event periods from individual event traces were compared. Remarkably, we found that the amount of catecholamine release and release dynamics depend on the stimulant concentration. No changes were observed at 10 mM K stimulation, but changes observed at 30 and 50 mM (, potentiation, increased number of molecules) were opposite to those at 100 mM (, depression, decreased number of events), revealing changes in exocytotic plasticity based on the concentration of the stimulant solution. These results show that molecular changes initiating exocytotic plasticity can be regulated by the concentration strength of the stimulant solution. These different effects on early plasticity offer a possible link between stimulation intensity and synaptic (or adrenal) plasticity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826951 | PMC |
| http://dx.doi.org/10.1039/d1sc05278k | DOI Listing |
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