Aims: The aim of this study was to evaluate the biocompatibility of resinous root canal sealers: Sealer 26, AH plus, and SK Seal Root Canal Sealer in the subcutaneous tissue of rats.
Subjects And Methods: Twenty-four Wistar rats received polyethylene tubes containing the sealers and empty tubes as control ( = 6). After 7, 15, 30, and 60 days, animals were killed and polyethylene tubes were removed with the surrounding tissues. The specimens were embedded in paraffin, processed for hematoxylin-eosin and immunohistochemistry assessed for fibronectin (FN) and tenascin (TN).
Statistical Analysis Used: Data were tabulated and analyzed via Kruskal-Wallis and Dunn's test ( < 0.05).
Results: All groups induced a moderate inflammatory reaction after 7 and 15 days ( > 0.05); after 30 days, a mild inflammatory infiltrate was observed in control groups, and moderate in sealers groups ( > 0.05); all groups showed mild inflammatory infiltrate at 60 days ( > 0.05). Overall, the fibrous capsule was considered thick only on the 7 day and became thin over time. All groups had expression for FN and TN in all analyzed periods, with high immunolabeling in sealers groups when comparing with the control group ( < 0.05).
Conclusion: All sealers demonstrated biocompatibility and induced FN and TN expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896128 | PMC |
| http://dx.doi.org/10.4103/jcd.jcd_628_20 | DOI Listing |
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