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A Rare Cause of Recurrent Gastrointestinal Bleeding: Gastric Metastasis of Merkel Cell Carcinoma.
Gastroenterol Nurs
November 2024
About the authors: Yakup Ülger, MD, is Associate Professor Dr., Department of Gastroenterology, Faculty of Medicine, Çukurova University, Adana, Turkey.
Re-exposition to ipilimumab plus nivolumab in metastatic Merkel cell carcinoma.
Front Immunol
December 2024
Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Background: Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous malignancy. Immune checkpoint inhibition (ICI) with PD-(L)1 blockade has significantly improved treatment outcomes in metastatic disease. In patients with primary resistance to PD-(L)1 inhibition, a high overall response rate (ORR) of 50% to later-line ipilimumab plus nivolumab (IPI/NIVO) has been demonstrated.
View Article and Find Full Text PDFPolyomaviruses and the risk of oral cancer: a systematic review and meta-analysis.
BMC Oral Health
December 2024
Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Objectives: Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and oral cancer.
Methods: The global online databases was used to identify relevant studies published between January 2000 and September 2024.
Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes.
Biomater Sci
December 2024
Ludwig-Maximilians-University, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstraße 5-13, Munich, 81377, Germany.
Polymeric carriers have long been recognized as some of the most effective and promising systems for nucleic acid delivery. In this study, we utilized an anionic di-block co-polymer, PEG-PLE, to enhance the performance of lipid-modified PEI (C14-PEI) nanoplexes for delivering Cas9 mRNA and sgRNA targeting KRAS G12S mutations in lung cancer cells. Our results demonstrated that PEG-PLE, when combined with C14-PEI at a weight-to-weight ratio of 0.
View Article and Find Full Text PDFThe Role of Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies.
Cancers (Basel)
November 2024
New York Proton Center, New York, NY 10035, USA.
Introduction: Skin cancer impacts a significant proportion of the population. While surgical management is often the mainstay of treatment, advanced or metastatic cutaneous malignancies require additional local and/or systemic therapies.
Methods: A review of the literature was performed studying the use of radiation therapy, chemotherapy, and immunotherapy for locally advanced or metastatic cutaneous malignancies.
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