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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Yale School of Medicine, New Haven, CT, USA.
Background: Affective cognition and emotion processing is impaired in amnestic Alzheimer's disease (AD), although less is known about atypical (AT) variants such as logopenic variant primary progressive aphasia (lvPPA) and posterior cortical atrophy (PCA). The affective blindsight pathway bypasses V1 via the superior colliculus-pulvinar route to activate the amygdala in cases of occipital lesioning and may explain maintenance of emotion identification and visual information processing in non-amnestic AD despite atrophy in visuospatial regions. We sought to characterize functional connectivity from key regions along the affective blindsight pathway in a clinically heterogeneous AD cohort.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Pittsburgh, Pittsburgh, PA, USA.
Background: Alzheimer's disease (AD) is classically viewed as a predominantly amnestic syndrome, with other cognitive and neuropsychiatric symptoms (NPS) being non-integral associations. Emerging Evidence suggests that within typical AD, these symptoms are core features from the onset.
Methods: We employed K-modes clustering on 2483 cognitively impaired (CI) individuals (CDR ≥ 0.
A cerebral clue in the stomach: Brain lesion leads to discovery of hidden gastric cancer.
Int J Surg Case Rep
December 2024
Department of Radio Oncology, School of Medicine Cancer Prevention Research Center Seyyed Al-Shohada Hospital Isfahan University of Medical Sciences, Iran. Electronic address:
Article Synopsis
- Brain metastases from gastric adenocarcinoma are very rare, accounting for only 0.1-0.16% of cases, and can present significant diagnostic challenges, especially when neurological symptoms appear before gastrointestinal ones.
- An 82-year-old male experienced non-specific neurological symptoms and was ultimately diagnosed with brain metastasis from a primary gastric tumor through advanced imaging and biopsies, underscoring the complexity of diagnosis in such cases.
- The case illustrates the necessity for a thorough diagnostic process and a coordinated treatment approach involving chemotherapy and targeted radiation therapy to effectively manage complex cancer presentations.
White matter changes in paediatric bipolar disorder: A systematic review of diffusion magnetic resonance imaging studiesA systematic review of diffusion magnetic resonance imaging studies.
J Affect Disord
December 2024
Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Background: Paediatric bipolar disorder (PBD) is characterized by severe mood fluctuations that deviate from typical childhood emotional development. Despite the efforts, the pathophysiology of this disorder is not well understood yet. In this review, we aimed to synthesize existing diffusion magnetic resonance imaging (dMRI) research findings in PBD.
View Article and Find Full Text PDFPossible Impact of Peripheral Inflammatory Factors and Interleukin-1β (IL-1β) on Cognitive Functioning in Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Progressive Supranuclear Palsy-Predominant Parkinsonism (PSP-P).
Int J Mol Sci
December 2024
Department of Neurology, Medical University of Warsaw, 03-242 Warsaw, Poland.
Progressive supranuclear palsy (PSP) is a tauopathic atypical parkinsonian syndrome. Recent studies suggest that inflammation may play a role in PSP pathogenesis, highlighting markers like the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and cytokines such as IL-1β and IL-6. This study aimed to assess the relationship between peripheral inflammatory markers and psychological abnormalities in PSP-RS and PSP-P patients.
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