AI Article Synopsis
- The study examined the toxic effects of nickel oxide nanoparticles (NiO-NPs) on Mediterranean mussels, focusing on gill, digestive gland, and hemolymph tissues over 96 hours.
- Key indicators of oxidative stress and antioxidant responses were assessed, revealing increased lipid peroxidation and varying levels of antioxidant enzymes like SOD, CAT, and GPx depending on nanoparticle concentration.
- Findings suggest that exposure to NiO-NPs negatively affects cell membrane stability and decreases hemocyte counts, indicating potential ecological harm in aquatic environments.
Article Abstract
In this study, the toxic effects of nickel oxide nanoparticles (NiO-NPs) on the model organism Mediterranean mussel (Mytilus galloprovincialis) gill, digestive gland, and hemolymph tissues for 96 h were investigated. Lipid peroxidation (MDA) determination was performed to reveal the oxidative stress generation potential of nanoparticles, and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) enzyme levels were measured to determine antioxidant responses. Lysosomal membrane stability and total hemocyte counts were performed to determine cytotoxic effects. All parameters were altered in different concentrations of NiO-NPs (2, 20, and 200 mg L). The SOD levels increased depending on the concentration (p < 0.05), and the increases in CAT, GPx, and GST levels were lower at 20 mg L concentration (p < 0.05). There was a slight difference between the exposure and the control groups in terms of GR enzyme. The MDA level increased in parallel with the concentration (p < 0.05), the stability of the cell membrane (p < 0.05), and the number of hemocyte cells decreased as a result of exposure (p < 0.05). The results emphasize that NiO-NPs may have negative effects on the aquatic environment.
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| http://dx.doi.org/10.1007/s12011-022-03189-4 | DOI Listing |
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