Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.thromres.2022.03.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Casein Kinase 2 Inhibitor, CX-4945, Induces Apoptosis and Restores Blood-Brain Barrier Homeostasis in In Vitro and In Vivo Models of Glioblastoma.
Cancers (Basel)
November 2024
Department of Chemical, Biological, Pharmaceutical, Environmental Science, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166 Messina, Italy.
In oncology, casein kinase 2 (CK2), a serine/threonine kinase, has a dual action, regulating cellular processes and acting as an oncogenic promoter. : This study examined the effect of CX-4945, a selective CK2 inhibitor, in a human U-87 glioblastoma (GBM) cell line, treated with CX-4945 (5, 10, and 15 μM) for 24 h. Similarly, the hCMEC/D3 cell line was used to mimic the blood-brain barrier (BBB), examining the ability of CX-4945 to restore BBB homeostasis, after stimulation with lipopolysaccharide (LPS) and then treated with CX-4945 (5, 10, and 15 μM).
View Article and Find Full Text PDFPrognostic performance of the Bova, sPESI, and Qanadli scores in patients with acute pulmonary embolism.
Acta Radiol
December 2024
Department of Emergency Medicine, Health Science University Antalya Training and Research Hospital, Antalya, Turkey.
Background: Acute pulmonary embolism (PE) is a disease with a serious prognosis and a high probability of death in the emergency department.
Purpose: To investigate the prediction of PE-related mortality and intensive care admission (ICU) of Qanadli (Qscore), Bova, and simplified Pulmonary Embolism Severity Index (sPESI) scores.
Material And Methods: This retrospective observational study consisted of all patients diagnosed with acute PE who were imaged under computed tomography pulmonary angiography (CTPA) for a total of 5 years between 1 June 2018 and 1 June 2023.
[Impact of 12-hour shifts on nurse, patient, and organizational outcomes. A critical review].
Assist Inferm Ric
September 2024
Dipartimento di scienze della Sanità Pubblica e Pediatriche, Università di Torino.
Unlabelled: . Impact of 12-hour shifts on nurse, patient and organizational outcomes. A critical review.
View Article and Find Full Text PDFA Heuristic Approach to Analysis of the Genetic Susceptibility Profile in Patients Affected by Airway Allergies.
Genes (Basel)
August 2024
Institute for High Performance Computing and Networking (ICAR), National Research Council (CNR), 90100 Palermo, Italy.
Allergic respiratory diseases such as asthma might be considered multifactorial diseases, having a complex pathogenesis that involves environmental factors and the activation of a large set of immune response pathways and mechanisms. In addition, variations in genetic background seem to play a central role. The method developed for the analysis of the complexities, as association rule mining, nowadays may be applied to different research areas including genetic and biological complexities such as atopic airway diseases to identify complex genetic or biological markers and enlighten new diagnostic and therapeutic targets.
View Article and Find Full Text PDFThe prognostic impact of unplanned invasive coronary angiography following coronary artery bypass grafting.
Eur J Cardiothorac Surg
August 2024
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.
Objectives: Myocardial ischaemia following coronary artery bypass grafting (CABG) is a potentially devastating complication. Nevertheless, the incidence, aetiology and prognostic relevance of unplanned coronary angiography (uCAG) remain understudied. We aimed to investigate the prevalence and outcome of patients undergoing urgent, uCAG in the postoperative period following CABG.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!