In this work, a novel triphenylamine derivative probe TPA-1 was designed and synthesized with a mechanism of aggregation induced emission (AIE) and twisted intramolecular charge transfer (TICT) in a microenvironment. It can be used for the detection of keratin with AIE enhanced characterization in near infrared (NIR) emission. The sensitivity and selectivity for keratin detection were also studied. In the physiological pH range, the detection of TPA-1 to keratin was not interfered by other proteins and amino acids, and had excellent specificity and photostability. TPA-1 can also be used for viscosity detection.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2022.114638DOI Listing

Publication Analysis

Top Keywords

ultra-sensitive near-infrared
4
near-infrared fluorescent
4
fluorescent probe
4
probe based
4
based triphenylamine
4
triphenylamine high
4
high selectivity
4
selectivity detecting
4
keratin
4
detecting keratin
4

Similar Publications

Surface-enhanced Raman spectroscopy is a powerful technique for the ultra-sensitive detection of organic analytes. In this paper, the preparation of SERS substrates based on silver nanorods (AgNRs) is proposed, exploiting a simple protocol which does not require complex procedures and/or sophisticated and expensive instrumentation. For this purpose, various syntheses of AgNRs were tested, and the best one for preparing the SERS active substrate proved to be the one which does not involve surfactants as nanoparticle stabilizers.

View Article and Find Full Text PDF

Ultrasensitive NIR fluorometric assay for inorganic pyrophosphatase detection via Cu-PPi interaction using bimetallic Au-Ag nanoclusters.

Anal Chim Acta

May 2024

Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University, Sector 14, Chandigarh, 160014, India. Electronic address:

Background: Inorganic pyrophosphatase (PPase) is key enzyme playing a key role in biochemical transformations such as biosynthesis of DNA and RNA, bone formation, metabolic pathways associated with lipid, carbohydrate and phosphorous. It has been reported that lung adenocarcinomas, colorectal cancer, and hyperthyroidism disorders can result from abnormal level of PPase. Therefore, it is of notable significance to develop simple and effective real time assay for PPase enzyme activity monitoring for screening of many metabolic pathways as well as for early disease diagnosis.

View Article and Find Full Text PDF

"Zero" Intrinsic Fluorescence Sensing-Platforms Enable Ultrasensitive Whole Blood Diagnosis and In Vivo Imaging.

Angew Chem Int Ed Engl

April 2024

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China.

Abnormal physiological processes and diseases can lead to content or activity fluctuations of biocomponents in organelles and whole blood. However, precise monitoring of these abnormalities remains extremely challenging due to the insufficient sensitivity and accuracy of available fluorescence probes, which can be attributed to the background fluorescence arising from two sources, 1) biocomponent autofluorescence (BCAF) and 2) probe intrinsic fluorescence (PIF). To overcome these obstacles, we have re-engineered far-red to NIR II rhodol derivatives that possess weak BCAF interference.

View Article and Find Full Text PDF

Highly sensitive fluorescence turn-OFF and reversible chemical sensor for Hg ion based on pyrene appended 2-thiohydantoin.

Chemosphere

March 2024

Functional Materials Laboratory, Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India. Electronic address:

A novel fluorometric chemical sensor (PY-2TH) based on 2-thiohydantoin (2TH) in conjugation with pyrene (PY) was designed by facile one-pot Knoevenagel condensation reaction and explored for the sensitive and selective detection of Hg ion in solution and solid state methods. Different analytical techniques like NMR and LC-MS concomitantly confirmed the structure of PY-2TH. Absorption and emission studies demonstrate positive solvatochromic effects indicating intramolecular charge transfer in polar solvents.

View Article and Find Full Text PDF

Butyrylcholinesterase (BChE) is a crucial hydrolytic enzyme predominantly synthesized in the liver, playing a significant role in conditions like liver disorders, diabetes, Alzheimer's disease, and fat metabolism regulation. This study aims to address the current limitations in visualizing BChE activity in diseases at various states by introducing an ultra-sensitive near-infrared fluorescent probe, FDCM-BChE. The probe was engineered to have several properties, such as a large Stokes shift, rapid response time, high stability, excellent selectivity, and low detection limits.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!