Background: Neuropathology is fundamental to neurology, neurosurgery, and neuroscience practice in general. In parts of Nigeria and other sub-Saharan African countries, Neuropathology is just emerging, and more so Paediatric Neuropathology. Paediatric Neuropathology encompasses diseases of brain, spinal cord, nerves and muscle, affecting infants, children and adolescents, many of which are surgically managed or biopsied for diagnosis.
Aim: To determine the pattern of neurosurgical lesions in children diagnosed in Benin-City, Nigeria.
Methods: A retrospective database study of biopsies from paediatric patients with neurosurgical lesions histologically evaluated at the Department of Pathology, University of Benin Teaching Hospital, Benin-City, Nigeria, between January 2007 and December 2020 was done. Demographic and clinical data were extracted from Departmental Records; histopathological diagnoses confirmed; and data analyzed using SPSS 20.0.
Results: A total of 178 biopsies reviewed. Ages ranged between 2 days and 16 years. Male: female ratio was 1.02:1. There were 87 spinal; 53 intracranial; 32 skull; and 9 scalp lesions. Commonest were Neural tube defects - 56.7% (mostly myelomeningoceles); Intracranial neoplasms - 20.22% (mostly pilocytic astrocytoma and embryonal tumors); Intracranial suppurative lesions -5.06% and dermoid/epidermoid cysts - 5.06%.
Conclusion: Most Paediatric neuropathological conditions encountered in our environment can be managed with good outcomes if correctly and promptly diagnosed. There is a need to channel resources into prevention and prenatal diagnoses of NTDs; early diagnosis and management of brain tumors and other intracranial lesions; and better management of otorhinolaryngologic and intracranial infections in children. Neuropathology training and capacity development is also needed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Author Correction: Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability.
Nat Commun
January 2025
Group Genome Instability in Tumors, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
Quantitative assessment of the generalizability of a brain tumor Raman spectroscopy machine learning model to various tumor types including astrocytoma and oligodendroglioma.
J Biomed Opt
January 2025
McGill University, Montreal Neurological Institute-Hospital, Montreal, Quebec, Canada.
Significance: Maximal safe resection of brain tumors can be performed by neurosurgeons through the use of accurate and practical guidance tools that provide real-time information during surgery. Current established adjuvant intraoperative technologies include neuronavigation guidance, intraoperative imaging (MRI and ultrasound), and 5-ALA for fluorescence-guided surgery.
Aim: We have developed intraoperative Raman spectroscopy as a real-time decision support system for neurosurgical guidance in brain tumors.
Classification of Fibro-osseous Tumors in the Craniofacial Bones using DNA Methylation and Copy Number Alterations.
Mod Pathol
January 2025
Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands; Department of Pathology, Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address:
Fibro-osseous tumors of the craniofacial bones are a heterogeneous group of lesions comprising cemento-osseous dysplasia (COD), cemento-ossifying fibroma (COF), juvenile trabecular ossifying fibroma (JTOF), psammomatoid ossifying fibroma (PsOF), fibrous dysplasia (FD), and low-grade osteosarcoma (LGOS) with overlapping clinicopathological features. However, their clinical behavior and treatment differ significantly, underlining the need for accurate diagnosis. Molecular diagnostic markers exist for subsets of these tumors, including GNAS mutations in FD, SATB2 fusions in PsOF, mutations involving the RAS-MAPK signaling pathway in COD, and MDM2 amplification in LGOS.
View Article and Find Full Text PDFLeptomeningeal Dissemination in Choroid Plexus Tumors: Magnetic Resonance Imaging Appearance and Risk Factors.
Children (Basel)
January 2025
Department of Neuroradiology, University Hospital Würzburg, D-97080 Würzburg, Germany.
Background: Intracranial choroid plexus tumors (CPT) are rare and primarily affect young children. Leptomeningeal dissemination (LMD) has been reported not only in high-grade choroid plexus carcinoma (CPC) but also in lower histological grades; however, a systematic evaluation of CPT-specific imaging characteristics remains lacking.
Methods: We analyzed the imaging characteristics of LMD in a single-center pediatric cohort of 22 CPT patients (thirteen choroid plexus papilloma (CPP), six atypical choroid plexus papilloma (aCPP), three CPC), comparing LMD features with those of the primary tumor.
Congenital Titinopathy: Comprehensive Characterization of the Most Severe End of the Disease Spectrum.
Ann Neurol
January 2025
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Unlabelled: Congenital titinopathy has recently emerged as one of the most common congenital muscle disorders.
Objective: To better understand the presentation and clinical needs of the under-characterized extreme end of the congenital titinopathy severity spectrum.
Methods: We comprehensively analyzed the clinical, imaging, pathology, autopsy, and genetic findings in 15 severely affected individuals from 11 families.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!