AI Article Synopsis
- The study looked at 446 patients with a blood disease called hereditary spherocytosis over the last 40 years.
- The number of patients getting their spleens removed (splenectomy) has gone down a lot, from 44% before 1990 to only 7% between 2011 and 2020.
- More older patients are having their spleens taken out now, and some people with milder cases are even having surgery, showing that doctors are more careful about the risks after spleen removal.
Article Abstract
We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011-2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressively increased (63% in children before 1990 to 88% in patients aged ≥20 years in 2011-2020). Our real-life experience showed that even a fraction of patients in the trait/mild categories (19/92, 21%) were splenectomised, whilst 30/78 (38%) in the moderate/severe groups were not. Overall, these data pinpoint to the increasing awareness about post-splenectomy thromboses and infections.
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| http://dx.doi.org/10.1111/bjh.18106 | DOI Listing |
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