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| http://dx.doi.org/10.1186/s13075-022-02758-1 | DOI Listing |
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Circulating Endocannabinoids and Cognitive Function in Older Adults.
Aging Dis
January 2025
School of Public Health, University of Haifa, Haifa 3498838, Israel.
The role of endogenous cannabinoids (endocannabinoids; eCBs) in cognitive-related processes has been demonstrated in preclinical studies. However, observational studies are lacking. We examined the associations of multiple circulating eCBs and eCB-like molecules with cognitive function in a sample of dementia-free older adults.
View Article and Find Full Text PDFElectroencephalographic (EEG) recordings in individuals with Fragile X Syndrome (FXS) and the mouse model of FXS ( KO) display cortical hyperexcitability at rest, as well as deficits in sensory-driven cortical network synchrony. A form of circuit hyperexcitability is observed in cortical slices of KO mice as prolonged persistent activity, or Up, states. It is unknown if the circuit mechanisms that cause prolonged Up states contribute to FXS-relevant EEG phenotypes.
View Article and Find Full Text PDFAccurate Enthalpies of Formation for Bioactive Compounds from High-Level Ab Initio Calculations with Detailed Conformational Treatment: A Case of Cannabinoids.
J Chem Theory Comput
January 2025
Thermodynamics Research Center, National Institute of Standards and Technology, Boulder, Colorado 80305-3337, United States.
Our recently developed approach based on the local coupled-cluster with single, double, and perturbative triple excitation [LCCSD(T)] model gives very efficient means to compute the ideal-gas enthalpies of formation. The expanded uncertainty (95% confidence) of the method is about 3 kJ·mol for medium-sized compounds, comparable to typical experimental measurements. Larger compounds of interest often exhibit many conformations that can significantly differ in intramolecular interactions.
View Article and Find Full Text PDFSex-specific maladaptive responses to acute stress upon in utero THC exposure are mediated by dopamine.
Pharmacol Res
December 2024
Dept. Biomedical Sciences, Div. Neuroscience and Clinical Pharmacology, University of Cagliari, Italy. Electronic address:
Article Synopsis
- * Research demonstrates that male rats exposed to THC during pregnancy exhibit altered dopamine activity and increased vulnerability to stress, affecting their sensorimotor functions.
- * The study found that the HPA axis's regulation of dopamine neurons differs by sex, influencing stress responses and sensorimotor gating, with potential for therapeutic interventions to correct these disruptions.
Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress.
Antioxidants (Basel)
October 2024
Department of Pharmacy, University of Salerno, Via G. Paolo II, Fisciano, 84084 Salerno, Italy.
The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent defects or dysfunctions are associated with the genesis/progression of several pathological conditions, including cancer, inflammation, and neurodegenerative disorders, that are directly or indirectly correlated to a wide set of events collectively named under the term "ER stress". Despite the recent increase in interest concerning ER activity, further research studies are needed to highlight all the mechanisms responsible for ER failure.
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