Objective: To determine the intravenous (i.v.) dose of esmolol needed to attenuate blood loss in patients undergoing posterior lumbar internal fixation (PLIF) surgery.
Methods: This study randomized patients to either the E5 or E10 group. Patients in the E5 group received a 0.25 mg/kg i.v. loading dose of esmolol before anaesthesia, followed by an infusion of 5 µg/kg/min throughout the operation. Patients in the E10 group received a 0.5 mg/kg i.v. loading dose of esmolol before anaesthesia, followed by an infusion of 10 µg/kg/min throughout the operation.
Results: The study analysed 33 patients: 16 in the E5 group and 17 in the E10 group. The mean ± SD blood loss at the end of surgery was significantly greater in the E5 than E10 group (586.3 ± 160.1 versus 347.7 ± 138.0 ml, respectively). The total amount of patient-controlled analgesia (PCA) used was significantly higher in the E5 than E10 group at 8 (26.1 ± 12.0 versus 17.5 ± 8.3 ml, respectively), 24 (58.4 ± 21.3 versus 44.1 ± 16.2 ml, respectively) and 48 h after surgery (90.0 ± 22.5 versus 69.3 ± 22.1 ml, respectively).
Conclusion: A continuous infusion of 10 µg/kg/min of esmolol can safely reduce blood loss during PLIF surgery. It was also shown to reduce postoperative PCA consumption.
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http://dx.doi.org/10.1177/03000605221078705 | DOI Listing |
Cureus
November 2024
College of Medicine, University of Zakho, Zakho, IRQ.
Background Autism spectrum disorders (ASDs) are a collection of neurological, psychological, and developmental anomalies that manifest in early life, affecting individuals across all racial, cultural, and socioeconomic groups. Its prevalence has grown significantly over the past 20 years. Exposure to digital devices has increased alongside the rise in ASD prevalence.
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November 2024
Guangxi University of Chinese Medicine, Nanning 530001, China. Electronic address:
J Biophotonics
December 2024
Department of Medical Engineering, University of South Florida, Tampa, Florida, USA.
J Clin Med
November 2024
Division of Neurotology, Department of Otorhinolaryngology, Complexo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
: It is known that balance disorders involve occupational hazards. However, the inverse relationship (between certain occupations and an increased incidence of vertigo or dizziness) has been scarcely studied. The objective of this work was to analyze the occupation of a group of patients with vertigo compared to the economically active general population and to evaluate the prevalence of occupational noise and/or vibration exposure in both groups.
View Article and Find Full Text PDFBMC Genomics
November 2024
Department of Animal Sciences, Georg-August-University Göttingen, Göttingen, Germany.
Background: The locus for naked neck (Na) in chickens reduces feather coverage and leads to increased heat dissipation from the body surface resulting in better adaptability to hot conditions. However, the Na gene is linked to significantly lower hatchability due to an increased late embryonic mortality. It has been argued that the causative gene GDF7 may have a direct pleiotropic effect on hatchability via its effect on muscle development.
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