AI Article Synopsis
- Low vitamin D levels during pregnancy may affect fetal immune development and potentially increase the risk of rheumatoid arthritis (RA) later in life.
- This study analyzed data from Danish registers to investigate the relationship between newborn vitamin D levels and the likelihood of developing RA in early adulthood, involving 805 RA cases and 2416 control individuals.
- Results indicated no significant association between vitamin D levels at birth and the risk of developing RA, as those with higher vitamin D concentrations did not show a lower risk compared to those with lower levels.
Article Abstract
Background: Low vitamin D in pregnancy may impair the development of the fetal immune system and influence the risk of later development of rheumatoid arthritis (RA) in the offspring. The aim was to examine whether lower 25-hydroxyvitamin D3 (25(OH)D) concentrations at birth were associated with the risk of developing RA in early adulthood. Methods: This case-cohort study obtained data from Danish registers and biobanks. Cases included all individuals born during 1981−1996 and recorded in the Danish National Patient Register with a diagnosis of RA with age >18 years at first admission. The random comparison consisted of a subset of Danish children. Vitamin D concentrations were measured in newborn dried blood. In total, 805 RA cases and 2416 individuals from the subcohort were included in the final analysis. Weighted Cox regression was used to calculate hazard ratio (HR). Results: The median (interquartile rage (IQR)) 25(OH)D concentrations among cases were 24.9 nmol/L (IQR:15.4;36.9) and 23.9 nmol/L (IQR:13.6;36.4) among the subcohort. There was no indication of a lower risk of RA among individuals in the highest vitamin D quintile compared with the lowest (HRadj.:1.21 (0.90;1.63)). Conclusion: The risk of RA in early adulthood was not associated with vitamin D concentrations at birth.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839203 | PMC |
| http://dx.doi.org/10.3390/nu14030447 | DOI Listing |
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