The explanation for deep neural networks has drawn extensive attention in the deep learning community over the past few years. In this work, we study the visual saliency, a.k.a. visual explanation, to interpret convolutional neural networks. Compared to iteration based saliency methods, single backward pass based saliency methods benefit from faster speed, and they are widely used in downstream visual tasks. Thus, we focus on single backward pass based methods. However, existing methods in this category struggle to successfully produce fine-grained saliency maps concentrating on specific target classes. That said, producing faithful saliency maps satisfying both target-selectiveness and fine-grainedness using a single backward pass is a challenging problem in the field. To mitigate this problem, we revisit the gradient flow inside the network, and find that the entangled semantics and original weights may disturb the propagation of target-relevant saliency. Inspired by those observations, we propose a novel visual saliency method, termed Target-Selective Gradient Backprop (TSGB), which leverages rectification operations to effectively emphasize target classes and further efficiently propagate the saliency to the image space, thereby generating target-selective and fine-grained saliency maps. The proposed TSGB consists of two components, namely, TSGB-Conv and TSGB-FC, which rectify the gradients for convolutional layers and fully-connected layers, respectively. Extensive qualitative and quantitative experiments on the ImageNet and Pascal VOC datasets show that the proposed method achieves more accurate and reliable results than the other competitive methods. Code is available at https://github.com/123fxdx/CNNvisualizationTSGB.
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http://dx.doi.org/10.1109/TIP.2022.3157149 | DOI Listing |
Med Image Comput Comput Assist Interv
October 2024
Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, USA.
Delineating the normative developmental profile of functional connectome is important for both standardized assessment of individual growth and early detection of diseases. However, functional connectome has been mostly studied using functional connectivity (FC), where undirected connectivity strengths are estimated from statistical correlation of resting-state functional MRI (rs-fMRI) signals. To address this limitation, we applied regression dynamic causal modeling (rDCM) to delineate the developmental trajectories of effective connectivity (EC), the directed causal influence among neuronal populations, in whole-brain networks from infancy to adolescence (0-22 years old) based on high-quality rs-fMRI data from Baby Connectome Project (BCP) and Human Connectome Project Development (HCP-D).
View Article and Find Full Text PDFWorld J Clin Cases
January 2025
Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 7470066, Yamaguchi, Japan.
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body. Recently, efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality (VR) technology. VR has been demonstrated to be an effective treatment for pain associated with medical procedures, as well as for chronic pain conditions for which no effective treatment has been established.
View Article and Find Full Text PDFJ Alzheimers Dis
January 2025
Cognivue, Inc., Victor, NY, USA.
Background: Cognivue is an FDA-cleared computerized cognitive test to screen for cognitive impairment included in the Bio-Hermes Study to test blood-based and digital biomarkers' ability to screen for mild cognitive impairment (MCI) and Alzheimer's disease (AD). A subset of cognitively normal individuals have amyloid deposition (Preclinical AD) but no current assessment can identify these individuals in the absence of expensive biomarkers.
Objective: We examined differences in Cognivue performance between amyloid positive and amyloid negative individuals and whether Cognivue could differentiate True Controls (cognitively normal/amyloid negative), Preclinical AD (cognitively normal/amyloid positive), and MCI due to AD (MCI-AD, cognitively impaired/amyloid positive).
Psychopharmacology (Berl)
January 2025
Edith Collins Centre for Translational Research in Alcohol, Drugs and Toxicology, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia.
Rationale: Both topiramate and naltrexone have been shown to affect neural alcohol cue reactivity in alcohol use disorder (AUD). However, their comparative effects on alcohol cue reactivity are unknown. Moreover, while naltrexone has been found to normalize hyperactive localized network connectivity implicated in AUD, no studies have examined the effect of topiramate on intrinsic functional connectivity or compared functional connectivity between these two widely used medications.
View Article and Find Full Text PDFBrain
January 2025
Department of Neurology, University of South Carolina, Columbia, SC 29203, USA.
Despite decades of advancements in diagnostic MRI, 30-50% of temporal lobe epilepsy (TLE) patients remain categorized as "non-lesional" (i.e., MRI negative or MRI-) based on visual assessment by human experts.
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