AI Article Synopsis
- Hypertension is a major global health issue, and agri-food by-products, particularly from the wine-making process, are being recognized for their potential as natural antihypertensive agents.
- Grape seed extracts have shown promising results in lowering blood pressure in both animal and human studies, while other by-products like grape stems, skins, and wine lees may also contribute, pending further research.
- The effectiveness of these by-products is primarily due to their ability to improve endothelial function and reduce oxidative stress, which are key factors in managing hypertension.
Article Abstract
Hypertension (HTN) is one of the leading causes of death in the world. Agri-food by-products are emerging as a novel source of natural antihypertensive agents allowing for their valorization and making food and agricultural industries more environmentally friendly. In this regard, wine making process generates large amounts of by-products rich in phenolic compounds that have shown potential to exert several beneficial effects including antihypertensive properties. The aim of this study was to review the blood pressure-lowering effects of winery by-products. In addition, molecular mechanisms involved in their bioactivity were also evaluated. Among the winery by-products, grape seed extracts have widely shown antihypertensive properties in both animal and human studies. Moreover, recent evidence suggests that grape stem, skin and pomace and wine lees may also have great potential to manage HTN, although more studies are needed in order to confirm their potential in humans. Improvement of endothelial dysfunction and reduction of oxidative stress associated with HTN are the main mechanisms involved in the blood pressure-lowering effects of these by-products.
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| http://dx.doi.org/10.1080/10408398.2022.2049202 | DOI Listing |
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