AI Article Synopsis
- The short half-life of drugs in the gastrointestinal tract often requires higher doses, which can lead to increased side effects from oral formulations.
- Researchers developed "Bacterioboat," a system using mesoporous nanoparticles that effectively carry drugs and can release them sustainably within the body.
- In studies, the oral delivery of 5-fluorouracil using Bacterioboat not only improved tumor shrinkage and life expectancy but also reduced side effects, making it a promising method for delivering drugs that are poorly soluble or permeable.
Article Abstract
The short half-life in the GI tract necessitates an excess of drugs causing side effects of oral formulations. Here, we report the development and deployment of Bacterioboat, which consists of surface-encapsulated mesoporous nanoparticles on metabolically active as a drug carrier suitable for oral administration. Bacterioboat showed up to 16% drug loading of its dry weight, intestinal anchorage around alveoli regions, sustained release, and stability in physiological conditions up to 24 hours. In vivo studies showed that oral delivery of 5-fluorouracil leads to increased potency, resulting in improved shrinkage of solid tumors, enhanced life expectancy, and reduced side effects. This novel design and development make this system ideal for orally administrable drugs with low solubility or permeability or both and even making them effective at a lower dose.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916724 | PMC |
| http://dx.doi.org/10.1126/sciadv.abh1419 | DOI Listing |
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