We examine the possibility that dark matter (DM) consists of a gapped continuum, rather than ordinary particles. A weakly interacting continuum (WIC) model, coupled to the standard model via a Z portal, provides an explicit realization of this idea. The thermal DM relic density in this model is naturally consistent with observations, providing a continuum counterpart of the "WIMP miracle." Direct detection cross sections are strongly suppressed compared to ordinary Z-portal WIMP, thanks to a unique effect of the continuum kinematics. Continuum DM states decay throughout the history of the Universe, and observations of cosmic microwave background place constraints on potential late decays. Production of WICs at colliders can provide a striking cascade-decay signature. We show that a simple Z-portal WIC model provides a fully viable DM candidate consistent with all current experimental constraints.
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http://dx.doi.org/10.1103/PhysRevLett.128.081807 | DOI Listing |
Alzheimers Dement
December 2024
Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Background: The 18F-AV-1451 radioligand enables in-vivo identification of tau neurofibrillary tangles that are considered as biomarkers of neurodegeneration in Alzheimer Disease (AD). However, off-target radioligand binding is also observed in basal ganglia, known as an iron-rich region. Hence, it is important to distinguish between radioligand-identified tissue neurodegeneration and iron-related radioligand binding effects.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Background: AD is defined by cortical amyloid-β (Aβ), tau neurofibrillary tangles, and neurodegeneration, pathological processes which may contribute to cognitive decline by altering large scale functional brain networks. To test this hypothesis, we examined whether plasma biomarkers of AD pathology (Aβ, phosphorylated tau [pTau-181]), astrogliosis (glial fibrillary acidic protein [GFAP]), and neuronal injury (neurofilament light chain [NfL]) related to longitudinal changes in resting-state functional connectivity (rsFC) in cognitively unimpaired participants from the Baltimore Longitudinal Study of Aging.
Method: Baseline plasma biomarkers were measured with Quanterix SIMOA assays.
Background: Robust methods are needed for preclinical evaluation of novel Alzheimer Disease (AD) therapies to accelerate drug discovery. Quantitative Gradient Recalled Echo (qGRE) MRI shows significant promise to provide insight into neurodegeneration in AD prior to atrophy development in humans, with qGRE R2t* metric (tissue-specific subcomponent of R2*) highlighting areas of low neuronal density (doi:10.3233/JAD-210503).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University, St. Louis, MO, USA.
Background: Robust methods are needed for preclinical evaluation of novel Alzheimer Disease (AD) therapies to accelerate drug discovery. Quantitative Gradient Recalled Echo (qGRE) MRI shows significant promise to provide insight into neurodegeneration in AD prior to atrophy development in humans, with qGRE R2t* metric (tissue-specific subcomponent of R2*) highlighting areas of low neuronal density (doi:10.3233/JAD-210503).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Background: The 18F-AV-1451 radioligand enables in-vivo identification of tau neurofibrillary tangles that are considered as biomarkers of neurodegeneration in Alzheimer Disease (AD). However, off-target radioligand binding is also observed in basal ganglia, known as an iron-rich region. Hence, it is important to distinguish between radioligand-identified tissue neurodegeneration and iron-related radioligand binding effects.
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