AI Article Synopsis
- * Using neuroimaging techniques, researchers categorized participants based on their gene status (gene expanded vs. gene non-expanded) and examined the thickness and surface area of the cortex.
- * Findings reveal that cortical development appears normal in mHTT carriers, despite notable differences in development observed in another brain region (the striatum).
Article Abstract
Background: Molecular studies provide evidence that mutant huntingtin (mHTT) affects early cortical development; however, cortical development has not been evaluated in child and adolescent carriers of mHTT.
Objective: To evaluate the impact of mHTT on the developmental trajectories of cortical thickness and surface area.
Methods: Children and adolescents (6-18 years) participated in the KidsHD study. mHTT carrier status was determined for research purposes only to classify participants as gene expanded (GE) and gene non-expanded (GNE). Cortical features were extracted from 3T neuroimaging using FreeSurfer. Nonlinear mixed effects models were conducted to determine if age, group, and CAG repeat were associated with cortical morphometry.
Results: Age-related changes in cortical morphometry were similar across groups. Expanded CAG repeat was not significantly associated with cortical features.
Conclusion: While striatal development is markedly different in GE and GNE, developmental change of the cortex appears grossly normal among child and adolescent carrier of mHTT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177765 | PMC |
| http://dx.doi.org/10.3233/JHD-210512 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!