Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8902250 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.826876 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Weak Vibration Generated by a Refrigerator on Protein Aggregation.
AAPS J
January 2025
Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Protein aggregates and particles in biopharmaceuticals can induce adverse immune responses in patients. Thus, suppression of the formation of protein aggregates and particles is important for the successful development of therapeutic proteins. Mechanical stresses, including agitation, are widely recognized as stress factors that generate protein aggregates and particles.
View Article and Find Full Text PDFPreliminary study on the ejection of microplastics from different types of face masks.
J Occup Environ Hyg
January 2025
Suganthi Devadason Marine Research Institute, Tuticorin, Tamil Nadu, India.
Face masks are strongly believed to be the best precaution to reduce the transmission of the SARS-CoV-2 virus, which resulted in an unprecedented surge in the production and use of personal respiratory protective equipment. Unfortunately, this surge led to improper disposal of used masks. This study aimed to assess the occurrence of microplastics (MPs) in used and unused surgical and cloth masks and N95 respirators.
View Article and Find Full Text PDFPbOI: A Lead Oxyhalide IR Optical Crystal with an Unprecedented [OPb] Chain Featuring a Wide Transmittance Range and Large Birefringence.
Inorg Chem
January 2025
Research Center for Crystal Materials, State Key Laboratory of Functional Materials and Devices for Special Environmental Conditions, Xinjiang Key Laboratory of Functional Crystal Materials, and Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Road, Urumqi 830011, P. R. China.
Among the infrared (IR) optical material systems, the heavy-metal oxyhalide system has become an emerging system in recent years. Introducing heavy-metal cations and halogen anions with large atomic numbers is conducive to widening the IR transparency window and improving the birefringence value. Our experiments focus on the PbO-PbI system and find a new lead oxyhalide, PbOI.
View Article and Find Full Text PDFPRRSV-2 nsp2 Ignites NLRP3 inflammasome through IKKβ-dependent dispersed trans-Golgi network translocation.
PLoS Pathog
January 2025
Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
The NLRP3 inflammasome is a fundamental component of the innate immune system, yet its excessive activation is intricately associated with viral pathogenesis. Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2), belonging to the family Arteriviridae, triggers dysregulated cytokine release and interstitial pneumonia, which can quickly escalate to acute respiratory distress and death. However, a mechanistic understanding of PRRSV-2 progression remains unclear.
View Article and Find Full Text PDFEnhanced silk production and pupal weight in Bombyx mori through CRISPR/Cas9-mediated circadian Clock gene disruption.
PLoS One
January 2025
Department of Biology, University of Padova, Padova, Italy.
The domesticated silkworm, Bombyx mori, is crucial for global silk production, which is a significant economic activity supporting millions of livelihoods worldwide. Beyond traditional silk production, the growing demand for insect larvae in cosmetics, biomedical products, and animal feed underscores the need to enhance B. mori productivity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!