Background: The olfactory function decline of patients with postoperative pituitary adenoma is a common phenomenon. In order to establish a surgical access to the skull base, the upper turbinate, posterior ethmoid chamber and sphenoid sinus need to be operated. We can objectively understand the patient's nasal situation through the scale during the hospital stay, but we know little about the patient's actual feelings and troubles in the home rehabilitation phase.
Methods: A qualitative study based on 15 semi-structured face-to-face interviews in a provincial comprehensive hospital was conducted. Participants were purposively selected until data saturation. Each interview was digitally recorded and lasted from 30 to 45 minutes. A trained and experienced interviewer collected all data. The Colaizzi method was used to analyze the data.
Results: A total of six themes were obtained, namely, the patient's perception of symptoms and any accompanying symptoms and signs related to olfactory function decline, negative emotions, decreased appetite, decreased sleep quality, decreased libido, and the need for the continuous care of patients.
Conclusions: A widespread occurrence of impaired smell and nasal function in patients with pituitary adenoma after endoscopic transsphenoidal surgery. It was also noted that nurses should intensify the postoperative nasal care of patients and develop good preventive measures to reduce their postoperative discomfort.
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http://dx.doi.org/10.21037/apm-21-2920 | DOI Listing |
J Appl Lab Med
January 2025
Service of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain.
Background: In prolactinoma diagnosis, current guidelines recommend prolactin (PRL) assessment, considering values exceeding 200 ng/mL highly suggestive of prolactinoma. However, subtler hyperprolactinemia is more common, and to rule out potential prolactinomas, pituitary resonance magnetic imaging (MRI) studies are necessary. These present limitations in terms of availability, costs, and delays in diagnosis.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Transcription factors (TFs), including steroidogenic factor-1 (SF-1), T-box transcription factor (TPIT) and pituitary transcription factor-1 (PIT-1), play a pivotal role in the cytodifferentiation of adenohypophysis. However, the impact of TFs on the growth patterns of nonfunctioning pituitary adenomas (NFPAs) remains unclear. This study aims to investigate the correlation between the expression of TFs and NFPAs growth patterns.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Background: Endoscopic endonasal transsphenoidal surgery is widely used to resect pituitary adenomas, yet its impact on olfactory function after resection of the posterosuperior nasal septum remains a concern. To optimize surgical techniques to preserve olfactory function, it is essential to understand the relationship between the extent of septal resection and olfactory outcomes.
Methods: This retrospective study analyzed 295 patients who underwent pituitary adenoma surgery.
Front Endocrinol (Lausanne)
January 2025
Department of Internal Medicine and Endocrinology, University Clinical Centre of the Medical University of Warsaw, Warsaw, Poland.
Pituitary
December 2024
Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Purpose: Uninsured and underinsured patients face notable healthcare disparities in neurosurgery, but limited literature exists on the impact of insurance on non-functioning pituitary adenomas (NFPAs). We investigated how insurance affects outcomes of endoscopic transsphenoidal pituitary surgery (ETPS) for NFPAs.
Methods: We retrospectively reviewed NFPA patients who underwent ETPS at our institution from 2012 to 2023.
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