Hunger games in the host cell: Toxoplasma traps and skins host mitochondria.

Cell Host Microbe

IAB, Team Host-Pathogen Interactions & Immunity to Infection, INSERM U1209, CNRS UMR 5309, Grenoble Alpes University, 38700 Grenoble, France. Electronic address:

Published: March 2022

Toxoplasma gondii actively tethers host mitochondria to its vacuole, altering their function. In a recent issue of Science, Li et al. demonstrate that Toxoplasma disarms host metabolic defenses by inducing the organelle to shed atypical large structures from its outer membrane to trap mitochondrial proteins that restrict parasite growth.

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http://dx.doi.org/10.1016/j.chom.2022.02.010DOI Listing

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