Toxoplasma gondii actively tethers host mitochondria to its vacuole, altering their function. In a recent issue of Science, Li et al. demonstrate that Toxoplasma disarms host metabolic defenses by inducing the organelle to shed atypical large structures from its outer membrane to trap mitochondrial proteins that restrict parasite growth.
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http://dx.doi.org/10.1016/j.chom.2022.02.010 | DOI Listing |
ACS Infect Dis
January 2025
Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India.
The complete tricarboxylic acid (TCA) cycle, comprising a series of 8 oxidative reactions, occurs in most eukaryotes in the mitochondria and in many prokaryotes. The net outcome of these 8 chemical reactions is the release of the reduced electron carriers NADH and FADH, water, and carbon dioxide. The parasites of the .
View Article and Find Full Text PDFInt J Mol Sci
January 2025
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
() has caused huge economic losses to the cattle industry. The interaction between and host cells is elucidated by screening and identifying the target protein of adhesin on the surface of the host cell membrane. However, the response mechanism of embryonic bovine lung (EBL) cells to infection is not yet fully understood.
View Article and Find Full Text PDFSyst Biol
January 2025
Simon F. S. Li Marine Science Laboratory, School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR.
Obtaining a timescale for bacterial evolution is crucial to understand early life evolution but is difficult owing to the scarcity of bacterial fossils. Here, we introduce multiple new time constraints to calibrate bacterial evolution based on ancient symbiosis. This idea is implemented using a bacterial tree constructed with genes found in the mitochondrial lineages phylogenetically embedded within Proteobacteria.
View Article and Find Full Text PDFMicrobiome
January 2025
Innovative Institute of Animal Health Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangdong Province, Guangzhou, 510025, China.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disease (ND). In recent years, multiple clinical and animal studies have shown that mitochondrial dysfunction may be involved in the pathogenesis of AD. In addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism have been considered to be important factors affecting central nervous system (CNS) homeostasis.
View Article and Find Full Text PDFVirulence
December 2025
Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, South Korea.
(Mab), a nontuberculous mycobacterium, is increasing in prevalence worldwide and causes treatment-refractory pulmonary diseases. However, how Mab rewires macrophage energy metabolism to facilitate its survival is poorly understood. We compared the metabolic profiles of murine bone marrow-derived macrophages (BMDMs) infected with smooth (S)- and rough (R)-type Mab using extracellular flux technology.
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