AI Article Synopsis
- YeiE is recognized as a key virulence factor in bacteria, and this study reveals its crystal structure when bound to sulfite ions (SO).
- The findings explain how YeiE senses sulfite and undergoes conformational changes to regulate gene expression related to sulfite tolerance.
- The research suggests a mechanism that allows gram-negative pathogens to withstand the innate immune response, offering potential strategies to combat bacterial infections.
Article Abstract
SignificanceYeiE has been identified as a master virulence factor of . In this study, we determined the crystal structures of the regulatory domain of YeiE in complex with its physiological ligand sulfite ion (SO). The structure provides the basis for the molecular mechanisms for sulfite sensing and the ligand-dependent conformational changes of the regulatory domain. The genes under the control of YeiE in response to sulfite were investigated to reveal the functional roles of YeiE in the sulfite tolerance of the bacteria. We propose the molecular mechanism underlying the ability of gram-negative pathogens to defend against the innate immune response involving sulfite, thus providing a strategy to control the pathogenesis of bacteria.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931317 | PMC |
| http://dx.doi.org/10.1073/pnas.2118002119 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!