(1) Background: Nowadays, pregnancy can be achieved by in vitro fertilisation (IVF) or by intracytoplasmic sperm injection (ICSI) for many infertile couples. However, implantation failure still remains a significant problem and it can be stressful for both patients and doctors. One of the key players for pregnancy achievement is the uterine environment. Hysteroscopy is the most reliable method to evaluate the uterine cavity and to identify any intauterine pathology. The aim of this retrospective study was to compare live birth ranges in between women who after a first failed IVF/ICSI attempt underwent a hysteroscopy and those who were evaluated by a transvaginal scan. (2) The retrospective study took place at the Assisted Reproductive Unit of the University Hospital of Ioannina, Greece, from 2017 to 2020. It included 334 women with normal findings in a repeat ultrasound scan after a failed IVF/ICSI trial, 137 of whom underwent in turn diagnostic hysteroscopy before the next IVF/ICSI. (3) Results: Live birth rates were higher in the study group (58/137 vs. 52/197 = 0.0025). Abnormal endometrial findings were identified in 30% of the patients of the study group. (4) Conclusions: The addition of hysteroscopy as an additional investigation to those patients with a first failed IVF/ICSI could improve the rates of live births. A properly conducted RCT could lead to a robust answer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910946 | PMC |
| http://dx.doi.org/10.3390/jcm11051217 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Medical treatment before in-vitro fertilization in patients with adenomyosis: a systematic review and meta-analysis.
J Assist Reprod Genet
December 2024
Department of Maternal and Child Health and Urology, Sapienza University, Viale Regina Elena, 324 - 00161, Rome, Italy.
The objective of this study is to evaluate if medical treatment before assisted reproductive technology (ART) improves the results in infertile patients with adenomyosis. A literature search was performed with EMBASE, PubMed, and Cochrane. The primary outcome was clinical pregnancy rate (CPR).
View Article and Find Full Text PDFGranulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging.
Hum Reprod
September 2024
Robinson Research Institute, School of Biomedicine, University of Adelaide, Adelaide, SA, Australia.
Study Question: Is oocyte developmental competence associated with changes in granulosa cell (GC) metabolism?
Summary Answer: GC metabolism is regulated by the LH surge, altered by obesity and reproductive aging, and, in women, specific metabolic profiles are associated with failed fertilization versus increased blastocyst development.
What Is Known Already: The cellular environment in which an oocyte matures is critical to its future developmental competence. Metabolism is emerging as a potentially important factor; however, relative energy production profiles between GCs and cumulus cells and their use of differential substrates under normal in vivo ovulatory conditions are not well understood.
Modelling and comparing the use of IVF and ICSI in Australia.
J Assist Reprod Genet
July 2024
Education Program in Reproduction and Development, Department of Obstetrics and Gynaecology, School of Clinical Sciences at Monash Health, Monash University, Clayton, 3168, Australia.
Purpose: This study estimates the need of IVF/ICSI in Australia as compared to its actual uptake.
Methods: We created a model estimating for the annual demand for IVF/ICSI in a hypothetical infertile population, using demographic data from medical literature and Australian government databases. For each category of infertility (tubal, severe male, endometriosis, anovulation and unexplained), our estimated need for IVF/ICSI was compared to the actual IVF/ICSI uptake (ANZARD 2019).
Elucidating the impact of Y chromosome microdeletions and altered gene expression on male fertility in assisted reproduction.
Hum Mol Genet
August 2024
Department of Physiology and Pharmacology, Pasteur Institute of Iran, No. 69,Pasteur Ave, Tehran, 1316943551, Iran.
Background: Genetic abnormalities like Y chromosome microdeletions are implicated in male infertility. This study investigated the association of azoospermia factor (AZF) region microdeletions with unsuccessful assisted reproductive techniques (ART), including in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).
Methods: This cross-sectional analysis study examined 80 Iranian oligospermic men (mean age 34 years) with prior failed ICSI and IVF cycles (IR.
Benefit from luteal phase progestin primed ovarian stimulation with clomiphene citrate supplementation in young women with diminished ovarian reserve: a retrospective study.
Zhejiang Da Xue Xue Bao Yi Xue Ban
May 2024
Center of Reproductive Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
Objectives: To compare the pregnancy outcomes of luteal phase and follicular phase progestin-primed ovarian stimulation protocol with clomiphene citrate supplementation (LPPOS+CC and FPPOS+CC) in young women with diminished ovarian reserve (DOR).
Methods: A total of 483 women aged ≤35 years with DOR, who underwent fertilization (IVF)/intracytoplasmic sperm injection (ICSI)/embryo transfer (ET) with controlled ovarian stimulation using LPPOS+CC (=257) or FPPOS+CC (=226) protocols during June 2018 and December 2021 at the First Affiliated Hospital of Wenzhou Medical University, were included in this retrospective study. The baseline characteristics, superovulation results, laboratory related indicators between the two groups, and the pregnancy outcomes of women who achieved at least one high-quality cleavage-stage embryo or good-morphology blastocyst were compared between the two groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!