The ability to comprehensively assess the diet of infants is essential for monitoring adequate growth; however, it is challenging to assess dietary intake with a high level of accuracy. Infants rely on surrogate reporting by caregivers. This study aimed to determine if surrogate reporters (e.g., caregivers) could use an image-based mobile food record adapted (baby mFR) to record infants' eating occasions, and via caregiver feedback, could assess the usability and feasibility of the baby mFR in recording infants' diets. This was a cross-sectional study in which surrogate reporters (e.g., caregivers) recorded all food and beverage intake (including human milk) of the infant over a 4-day period. Trained research staff evaluated all images submitted during data collection for different indicators of quality. All surrogate reporters were asked to complete a usability questionnaire at the end of the 4-day data collection period. Basic descriptive analyses were performed on the infants 3-12 months of age ( = 70). A total of 91% ( = 64) of surrogate reporters used the baby mFR to record their infants' eating occasions. The mean number of images submitted daily per participant via the mFR was 4.2 (SD 0.2). A majority of submitted images contained the fiducial marker and the food and/or beverage was completely visible. The mFR was found to be easy to use; however, suggestions were provided to increase utility of the application such as the inclusion of a bottle button and reminders. An image-based dietary assessment method using a mobile app was found to be feasible for surrogate reporters to record an infant's food and beverage intake throughout the day.
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http://dx.doi.org/10.3390/nu14051075 | DOI Listing |
J Virol
December 2024
Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC), Madrid, Spain.
Unlabelled: Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic disease that causes severe disease in both domestic and wild ungulates and humans, making it a significant threat to livestock and public health. The RVFV genome consists of three single-stranded, negative-sense RNA segments differing in size: small (S), medium (M), and large (L). Segment S encodes the virus nucleoprotein N and the virulence-associated factor non-structural (NSs) protein in opposite orientations, separated by an intergenic region (IGR).
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
January 2025
From the Departments of Rheumatology and Clinical Immunology (R.R., A.E.H., R.U.) and Neuropathology (R.R., H.R.), Charité - Universitätsmedizin Berlin; Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Immune Dynamics (A.E.H., R.G.) and Biophysical Analytics (A.R., R.A.N.), Berlin; NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin (F.P.), Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max-Delbrueck Center for Molecular Medicine (F.P.); and Dynamic and Functional in vivo Imaging, Freie Universität (R.A.N.) Berlin, Germany.
Background And Objectives: Inflammatory demyelinating diseases of the CNS, chief among them multiple sclerosis (MS), are a major cause of disability in young adults. Early manifestations of MS commonly involve visual dysfunction, which is often caused by optic neuritis and is accompanied by quantifiable structural changes of the anterior visual pathway. Retinal optical coherence tomography (OCT) has emerged as an important tool for clinical assessment of these structural alterations, but the underlying pathobiological mechanisms and temporal dynamics are yet poorly understood at a cellular level.
View Article and Find Full Text PDFOpen Biol
October 2024
Systems and Cellular Medicine, University of Dundee, Dundee DD1 9SY, UK.
The development of therapies to combat neurodegenerative diseases is widely recognized as a research priority. Despite recent advances in understanding their molecular basis, there is a lack of suitable early biomarkers to test selected compounds and accelerate their translation to clinical trials. We have investigated the utility of reporters of cytoprotective pathways (e.
View Article and Find Full Text PDFFront Microbiol
September 2024
College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Introduction: Senecavirus A (SVA), belonging to the genus in the family , is an emerging pathogen causing vesicular disease in pigs. The main clinical manifestations of SVA infection include high mortality in neonatal piglets, skin ulceration, and vesicular lesions. So far, there is no commercially available vaccines or drugs against SVA.
View Article and Find Full Text PDFACS Omega
August 2024
Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.
Human -alkylguanine-DNA-transferase (hAGT) is a repair protein that provides protection from mutagenic events caused by -alkylguanine lesions. As this stoichiometric activity is tissue-specific, indicative of tumor status, and correlated to chemotherapeutic success, tracking the activity of hAGT could prove to be informative for disease diagnosis and therapy. Herein, we explore two families of emissive -methyl- and -benzylguanine analogs based on our previously described and , thieno- and isothiazolo-guanine surrogates, respectively, as potential reporters.
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