Downregulation of Promotes Cell Growth and Motility in Human Gastric Cancer.

Gastric cancer is a common tumor, with a high mortality rate. The severity of gastric cancer is assessed by TNM staging. Long noncoding RNAs (lncRNAs) play a role in cancer treatment; investigating the clinical significance of novel biomarkers associated with TNM staging, such as lncRNAs, is important. In this study, we investigated the association between the expression of the lncRNA and gastric cancer stage. expression was lower in stage IV than in stages I, II, and III. The depletion of promoted cell proliferation, cell cycle progression, apoptosis, cell motility, and invasiveness. downregulation increased the epithelial-to-mesenchymal transition, as indicated by increased TRAIL signaling and decreased RUNX1 interactions. The interaction of the transcription factors RELA, IRF1, ESR1, AR, POU5F1, TRIM28, and GATA1 with affected the degree of the malignancy of gastric cancer by modulating gene transcription. The present study identified and seven transcription factors as potential biomarkers and therapeutic targets for the treatment of gastric cancer.