AI Article Synopsis
- A study examined the effects of the antibiotics ethambutol and rifampin on the treatment outcomes for patients with Mycobacterium avium complex pulmonary disease (MAC-PD).
- The researchers found no link between high minimum inhibitory concentrations (MICs) for these drugs and the failures in treatment among the 158 patients analyzed.
- Although a significant percentage of MAC isolates showed resistance to ethambutol (87%) and rifampin (59%), mutations in key resistance genes were infrequently detected (only 4% of resistant isolates).
Article Abstract
We evaluated the associations between the activities of ethambutol and rifampin and clinical outcomes of Mycobacterium avium complex (MAC) pulmonary disease (PD). Among 158 patients with MAC-PD, there was no relationship between high MICs for ethambutol and/or rifampin and treatment failure for MAC-PD. Ethambutol and rifampin resistance was common among MAC isolates (rates of 87% and 59%, respectively), but mutations in , , and were rare, with detection in only 4% of the drug-resistant MAC isolates.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017369 | PMC |
| http://dx.doi.org/10.1128/aac.02027-21 | DOI Listing |
Publication Analysis
Top Keywords
ethambutol rifampin
12
rifampin clinical
8
clinical outcomes
8
outcomes mycobacterium
8
mycobacterium avium
8
avium complex
8
pulmonary disease
8
mac isolates
8
relationship resistance
4
ethambutol
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!