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evades neutrophil oxidative stress responses providing a safer niche for nontypeable . | LitMetric

AI Article Synopsis

  • Nontypeable Haemophilus influenzae (NTHi) is a bacteria often linked to worsening chronic obstructive pulmonary disease (COPD), which involves inflammation and oxidative stress in the lungs.
  • Research finds that NTHi triggers more reactive oxygen species (ROS) and neutrophil extracellular traps (NET) production in immune cells than other bacteria, while also disrupting these immune responses.
  • Understanding how these bacteria evade immune responses could lead to new treatments for COPD and related conditions where they are present.

Article Abstract

and nontypeable (NTHi) are pathogenic bacteria frequently associated with exacerbation of chronic obstructive pulmonary disease (COPD), whose hallmark is inflammatory oxidative stress. Neutrophils produce reactive oxygen species (ROS) which can boost antimicrobial response by promoting neutrophil extracellular traps (NET) and autophagy. Here, we showed that induces less ROS and NET production in differentiated HL-60 cells compared to NTHi. It is also able to actively interfere with these responses in chemically activated cells in a phagocytosis and opsonin-independent and contact-dependent manner, possibly by engaging host immunosuppressive receptors. subverts the autophagic pathway of the phagocytic cells and survives intracellularly. It also promotes the survival of NTHi which is otherwise susceptible to the host antimicrobial arsenal. In-depth understanding of the immune evasion strategies exploited by these two human pathogens could suggest medical interventions to tackle COPD and potentially other diseases in which they co-exist.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899411PMC
http://dx.doi.org/10.1016/j.isci.2022.103931DOI Listing

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