The identification of substance use disorders (SUD) can be challenging due to the complexity of symptoms involved and the limited time that non-clinical personnel often have to assess associated symptoms. This study initially explores the efficacy of the Substance Use Disorder Screening Instrument (ICTUS) in identifying symptoms associated with SUD among people living in and out of prisons. The ICTUS was developed by adapting the items of the Simple Screening Instrument for Substance Abuse (SSI-SA) to the DSM-5 criteria. ICTUS shows the ability to effectively identify those who meet diagnostic criteria for SUD when comparing percentages of substance use and diagnosis of SUD according to CIDI, a clinical measure. These results reveal that ICTUS can be considered as an appropriate alternative to objectively assess the symptoms associated with SUD and inform the planning and service provision process.
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Am J Emerg Med
December 2024
Department of Health Policy & Organization, School of Public Health, The University of Alabama at Birmingham, Birmingham, AL, USA; Center for Outcomes and Effectiveness Research and Education, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Background: Leaving before medically advised (BMA) is a significant issue in the US healthcare system, leading to adverse health outcomes and increased costs. Despite previous research, multi-year studies using up-to-date nationwide emergency department (ED) data, are limited. This study examines factors associated with leaving BMA from EDs and trends over time, before and during the COVID-19 pandemic.
View Article and Find Full Text PDFJ Trauma Nurs
January 2025
Author Affiliations: Castner Incorporated, Grand Island, NY (Dr Castner); Health Policy, Management, and Behavior, School of Public Health, University at Albany, Albany, New York (Dr Castner); Stony Brook University School of Nursing, Stony Brook, NY (Ms Zazzera); and Nursing Research and Evidence-Based Practice, Penn Medicine Lancaster General Health, Lancaster, PA (Dr Burchill).
Background: Trauma population health indicators are worsening in the United States. Nurses working in trauma care settings require specialized training for patient care. Little is known about national enumeration of nurses who hold skill-based trauma certificates.
View Article and Find Full Text PDFInt Microbiol
January 2025
Phytopathology Unit, Department of Plant Protection, Ecole Nationale d'Agriculture de Meknès, Km 10, Rte Haj Kaddour, BP S/40, 50001, Meknes, Morocco.
Olive trees are susceptible to various diseases, notably root rot caused by Pythium spp., which presents significant challenges to cultivation. Conventional chemical control methods have limitations, necessitating exploration of eco-friendly alternatives like biological control strategies.
View Article and Find Full Text PDFTurk J Pediatr
December 2024
Department of Pediatric Neurology, Ankara Bilkent City Hospital, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Türkiye.
Background: Metoclopramide, a dopamine antagonist employed for its antiemetic effects, can precipitate neuropsychiatric adverse effects, including extrapyramidal symptoms and, in a few instances, acute psychosis. Although there have been reports of metoclopramide-induced psychosis in elderly individuals, there is no documentation of such incidents in children as far as we are aware.
Case Presentation: This case report describes an 11-year-old girl with a history of mild intellectual disability and attention deficit hyperactivity disorder, managed with 10 mg of methylphenidate daily.
Acta Pharm Sin B
December 2024
State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Interleukin-1 receptor-related kinase (IRAK4) is a widely expressed serine/threonine kinase involved in the regulation of innate immunity. IRAK4 plays a pivotal role as a key kinase within the downstream signaling pathway cascades of interleukin-1 receptors (IL-1R) and Toll-like receptors (TLRs). The signaling pathways orchestrated by IRAK4 are integral to inflammatory responses, and its overexpression is implicated in the pathogenesis of inflammatory diseases, autoimmune disorders, and cancer.
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