AI Article Synopsis
- The study investigates the specific causes of infertility and appropriate ART management in women with cystic fibrosis (CF) compared to women without CF.
- A multicentre case-control study was conducted with 17 CF women compared to 34 non-CF women, focusing on infertility causes, ART types, and pregnancy outcomes.
- Results indicated that while infertility causes were similar, IUI appeared as effective as IVF/ICSI for CF patients, with more embryos obtained in the CF group; FEV1 levels and genetic factors did not significantly impact ART outcomes.
Article Abstract
Research Question: Unlike in men, a very limited number of studies were focused on the specificity of ART management of cystic fibrosis (CF) in women. The purpose of this study was to determine the causes of infertility in patients, the appropriate ART treatment, and their prognosis in terms of pregnancy.
Design: We conducted a multicentre analytical case-control study including CF women who were age-matched to non-CF women. We reported the causes of infertility, the ART management type and pregnancy outcomes.
Results: 17 cases were compared to 34 controls. There was no significant difference between the groups concerning cause infertility. There was a non-statistically significant trend with a lower antral follicle count in CF compared to controls (19.5 versus 26.8, p=0.08). IUI seemed to be as successful as IVF/ICSI in CF as opposed to controls where the IVF/ICSI was the most effective (in CF group for HCG >100 UI/L: 38.8% vs. 36.8%, p=0.4175). There were more embryos obtained in CF than in controls (3.1 versus 1.6, p=0.02). The number of oocytes and embryos obtained and pregnancy outcomes remained similar between DF508 homozygous group and others CFTR mutations group. The results of ART procedures and pregnancy evolution were not influenced by FEV1.
Conclusion: In absence of any other pathology, IUI may be first option for CF women. If insemination fails, IVF with a low dose of gonadotropins may be more appropriate to prevent the risk of hyperstimulation syndrome. FEV1 and genetic do not seem to be contributing factors in the prognosis of ART.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898889 | PMC |
| http://dx.doi.org/10.3389/fendo.2022.773753 | DOI Listing |
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