AI Article Synopsis
- Non-invasive collection of mRNA from skin surface lipids (SSLs) offers insights into skin health and diseases by analyzing the genetic material found in the skin's natural oils.
- Research shows that human mRNAs are protected in SSLs, particularly from sebaceous glands, epidermis, and hair follicles, making them viable for study.
- In patients with atopic dermatitis, there are notable changes in gene expression related to inflammation and skin function, highlighting the potential of SSL-RNA analysis for better understanding skin conditions.
Article Abstract
Non-invasive acquisition of mRNA data from the skin can be extremely useful for understanding skin physiology and diseases. Inspired by the holocrine process, in which the sebaceous glands secrete cell contents into the sebum, we focused on the possible presence of mRNAs in skin surface lipids (SSLs). We found that measurable levels of human mRNAs exist in SSLs, where the sebum protects them from degradation by RNases. The AmpliSeq transcriptome analysis was modified to measure SSL-RNA levels, and our results revealed that the SSL-RNAs predominantly comprised mRNAs derived from sebaceous glands, the epidermis, and hair follicles. Analysis of SSL-RNAs non-invasively collected from patients with atopic dermatitis revealed increased expression of inflammation-related genes and decreased expression of terminal differentiation-related genes, consistent with the results of previous reports. Further, we found that lipid synthesis-related genes were downregulated in the sebaceous glands of patients with atopic dermatitis. These results indicate that the analysis of SSL-RNAs is a promising strategy to understand the pathophysiology of skin diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907185 | PMC |
| http://dx.doi.org/10.1038/s42003-022-03154-w | DOI Listing |
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