AI Article Synopsis
- Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is primarily known for causing infections in newborns but can also lead to serious diseases in non-pregnant adults, particularly in Southeast Asia.
- A study sequenced 12 samples of the GBS ST283 genotype from adult patients in Thailand and combined this data with existing sequences to analyze the bacteria's population dynamics and transmission history.
- The research identified potential drug resistance genes and validated their resistance phenotypes through experiments, providing insights into the historical spread of GBS ST283 in the region.
Article Abstract
Streptococcus agalactiae, also known as Lancefield Group B Streptococcus (GBS), is typically regarded as a neonatal pathogen; however, several studies have shown that the bacteria are capable of causing invasive diseases in non-pregnant adults as well. The majority of documented cases were from Southeast Asian countries, and the most common genotype found was ST283, which is also known to be able to infect fish. This study sequenced 12 GBS ST283 samples collected from adult patients in Thailand. Together with publicly available sequences, we performed temporo-spatial analysis and estimated population dynamics of the bacteria. Putative drug resistance genes were also identified and characterized, and the drug resistance phenotypes were validated experimentally. The results, together with historical records, draw a detailed picture of the past transmission history of GBS ST283 in Southeast Asia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907273 | PMC |
| http://dx.doi.org/10.1038/s41598-022-08097-0 | DOI Listing |
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