Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970453 | PMC |
| http://dx.doi.org/10.1681/ASN.2022020157 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assembly and functional mechanisms of plant NLR resistosomes.
Curr Opin Struct Biol
January 2025
School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China. Electronic address:
Nucleotide-binding and leucine-rich repeat (NLR) proteins are essential intracellular immune receptors in both animal and plant kingdoms. Sensing of pathogen-derived signals induces oligomerization of NLR proteins, culminating in the formation of higher-order protein complexes known as resistosomes in plants. The NLR resistosomes play a pivotal role in mediating the plant immune response against invading pathogens.
View Article and Find Full Text PDFConnecting dots: Preclinical foundations to clinical realities of PDE4 inhibitors in Alzheimer's disease.
Inflammopharmacology
January 2025
Department of Pharmacology, Central University of Punjab, Bathinda, 151001, Punjab, India.
Alzheimer's Disease (AD), a progressive and age-associated neurodegenerative disorder, is primarily characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. Despite advances in targeting Aβ-mediated neuronal damage with anti-Aβ antibodies, these treatments provide only symptomatic relief and fail to address the multifactorial pathology of the disease. This necessitates the exploration of novel therapeutic approaches and a deeper understanding of molecular signaling mechanisms underlying AD.
View Article and Find Full Text PDFGenerations X, Y, Z: The Moderating Role of Self-Reliance in Relationships Between Loneliness, Social Media Addiction, and Life Satisfaction in Men.
Cyberpsychol Behav Soc Netw
January 2025
Israel-School of Social Work, Ariel University, Ariel, Israel.
In today's sociocultural milieu, characterized by pervasive social media and evolving conceptions of masculinity, this study examines the interplay among loneliness, social media addiction, self-reliance, and life satisfaction across Generations (Gen) X, Y, and Z. Employing a comprehensive model, the study explores social media addiction as a mediator between loneliness and life satisfaction, with a focus on the moderating role of the pivotal masculine trait of self-reliance in the loneliness-social media addiction relationship. Based on an online survey of 775 Israeli men aged 18-58, the findings reveal unique generational patterns.
View Article and Find Full Text PDFA microfluidic coculture model for mapping signaling perturbations and precise drug screening against macrophage-mediated dynamic myocardial injury.
Acta Pharm Sin B
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Macrophage-mediated inflammation plays a pivotal role in cardiovascular disease pathogenesis. However, current cell-based models lack a comprehensive understanding of crosstalk between macrophages and cardiomyocytes, hindering the discovery of effective therapeutic interventions. Here, a microfluidic model has been developed to facilitate the coculture of macrophages and cardiomyocytes, allowing for mapping key signaling pathways and screening potential therapeutic agents against inflammation-induced dynamic myocardial injury.
View Article and Find Full Text PDFIsolation and Identification of Mercury-Dissolved Organic Matter Complexes in Mercury-Humic Acid Suspensions.
Rapid Commun Mass Spectrom
April 2025
Department of Civil and Environmental Engineering, Syracuse University, Syracuse, New York, USA.
Rationale: The complexation with dissolved organic matter (DOM) is a pivotal factor influencing transformations, transport, and bioavailability of mercury (Hg) in aquatic environments. However, identifying these complexes poses a significant challenge because of their low concentrations and the presence of coexisting ions.
Methods: In this study, mercury-dissolved organic matter (Hg-DOM) complexes were isolated through solid-phase extraction (SPE) from Hg-humic acid suspensions, and complexes were putatively identified using ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!