Neonatal thyrotoxicosis with maternal hypothyroidism.

BMJ Case Rep

Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India

Published: March 2022

Neonatal Graves' is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%-5% of infants born to a mother with Graves' disease. Here, we report a unique case of transient neonatal thyrotoxicosis with positive TSI in a premature neonate born to the mother with primary hypothyroidism. A short course of antithyroid drug treatment leads to significant clinical and biochemical improvement followed by complete recovery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915356PMC
http://dx.doi.org/10.1136/bcr-2021-247865DOI Listing

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