AI Article Synopsis
- The study addresses the challenges of stabilizing titanium (Ti) ions in water, which has limited their use in important applications like medical imaging and catalysis.
- Researchers performed a detailed screening of bidentate chelators for Ti in aqueous solutions, involving both thermodynamic assessments and structural analyses.
- The hexadentate chelators TREN-CAM and THP showed exceptional potential for creating stable compounds with Ti for positron emission tomography (PET) imaging, specifically demonstrating great kit-formulation capabilities and in vivo stability.
Article Abstract
Despite its prevalence in the environment, the chemistry of the Ti ion has long been relegated to organic solutions or hydrolyzed TiO polymorphs. A knowledge gap in stabilizing molecular Ti species in aqueous environments has prevented the use of this ion for various applications such as radioimaging, design of water-compatible metal-organic frameworks (MOFs), and aqueous-phase catalysis applications. Herein, we show a thorough thermodynamic screening of bidentate chelators with Ti in aqueous solution, as well as computational and structural analyses of key compounds. In addition, the hexadentate analogues of catechol (benzene-1,2-diol) and deferiprone (3-hydroxy-1,2-dimethyl-4(1H)-pyridone), TREN-CAM and THP respectively, were assessed for chelation of the Ti isotope (t =3.08 h, β =85 %, E =439 keV) towards positron emission tomography (PET) imaging applications. Both were found to have excellent capacity for kit-formulation, and [ Ti]Ti-TREN-CAM was found to have remarkable stability in vivo.
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| http://dx.doi.org/10.1002/anie.202201211 | DOI Listing |
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