A method for the photoinduced evolution of atomic oxygen from pyridazine -oxides was developed. This underexplored oxygen allotrope mediates arene C-H oxidation within complex, polyfunctional molecules. A water-soluble pyridazine -oxide was also developed and shown to promote photoinduced DNA cleavage in aqueous solution. Taken together, these studies highlight the utility of pyridazine -oxides as photoactivatable O(P) precursors for applications in organic synthesis and chemical biology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559729 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.2c00227 | DOI Listing |
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