AI Article Synopsis
- The study investigates antimicrobial resistance (AMR) in enteric bacterial pathogens from environmental sources in Ethiopia, highlighting it as a pressing public health issue not included in sustainable development goals.
- It involved analyzing 180 environmental samples using standard microbiological methods and statistics, revealing significant prevalence rates of AMR pathogens in wastewaters and solid waste areas.
- The results suggest that contaminated waste discharges are major contributors to AMR in local water bodies, underlining a critical public health concern that might only represent the initial findings in a broader issue.
Article Abstract
Background And Aim: Antimicrobial resistance (AMR) resulting in the most significant public health and economic threat. Unfortunately, it is one of the missing topics on sustainable development goals (SDGs). Therefore, this laboratory-based study aimed at determining enteric bacterial pathogens and their antibiotic-resistant patterns from the environmental sources in different regions of Ethiopia.
Methods: A laboratory-based cross-sectional study was conducted by following the standard microbial culture and the Kirby-Bauer disc diffusion method for identification and AMR patterns of the enteric bacteria using a total of 180 environmental samples from January through June 2020. We employed descriptive statistics to examine the prevalence rate, comparability of results, and summary of AMR patterns of enteric bacteria and a 95% confidence Interval (CI) for considering the statistical significance and give conclusions by using Stata 14.1.
Results: The mean prevalence rates (SD) at 95% CI of AMR enteric bacterial pathogens were 53.13 (2.51)% (52.31, 53.95), 45 (1.85)% (44.40, 45.60), 32.5 (3.01)% (31.10, 33.00), and 31.12 (1.95)% (30.80, 31.45) in Wastewaters, leachate from solid waste dumping sites, waste receiving water bodies (Lake Tana at Bahir Dar and Boye Wetland at Jimma), and Soils sequentially. Specifically, , , and were 90 (3.10)% (89.00, 91.10), 67.5 (2.58)% (66.72, 68.41), and 45(1.58)% (44.48, 45.52), respectively, investigated in wastewater. In addition, solid waste dumping sites were contaminated with 80 (3.97)% (79.34, 80.66), 61 (2.87)% (59.06, 60.94), and 42 (5.67)% (40.15, 43.85). This study implies that the waste discharges are the main source of contamination for AMR pathogens to the two aquatic water bodies.
Conclusion: The finding indicated that wastewater and solid waste dumping sites were important sources for AMR enteric pathogens. The finding might have indicated the tip of the iceberg about the environmental contamination with antimicrobial-resistant enteric pathogens.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889915 | PMC |
| http://dx.doi.org/10.1002/hsr2.521 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Aetiological, seasonal and antibiotic susceptibility patterns of diarrhoeal diseases in Bhutan (2016-2022): a retrospective study of surveillance data.
BMJ Open
January 2025
Enteric Zoonotic and Vector-Borne Disease Laboratory, Royal Centre for Disease Control, Thimphu, Bhutan.
Objectives: This study aimed to identify the aetiological spectrum, seasonal distribution and antimicrobial resistance patterns of diarrhoeal diseases in Bhutan.
Study Design And Setting: The study used a cross-sectional, retrospective analysis of secondary data gathered through a passive, hospital-based sentinel surveillance for diarrhoeal disease across 12 hospitals, representing Bhutan's demographically diverse regions.
Participants: A total of 3429 participants' data of all age groups who presented with diarrhoea at sentinel hospitals between 1 January 1 2016 and 31 December 2022 were analysed.
When is it a sexually transmitted infection? Intimate contact transmission of pathogens not traditionally defined as STIs.
Curr Opin Infect Dis
February 2025
Infectious Diseases Unit, Vita-Salute San Raffaele University.
Purpose Of Review: Several microorganisms, which are not traditionally considered sexually transmitted infections (STIs), are capable of sexual transmission and have the potential to cause global outbreaks. The aim of this review is to describe pathogens which are not traditionally defined as STIs, to grant insight on current and potential outbreaks and call for clinical vigilance among members of key populations.
Recent Findings: Recent findings emphasize that several pathogens, not traditionally classified as STIs, can be sexually transmissible.
Preliminary establishment and evaluation of a rapid detection method for GII human norovirus based on time-resolved fluorescence chromatography.
Anal Methods
January 2025
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, People's Republic of China.
Article Synopsis
- Human norovirus leads globally in causing stomach infections across all ages.
- A new detection method using time-resolved fluorescence microsphere immunochromatography was developed, maximizing sensitivity and speed for identifying the VP1 protein of norovirus GII in only 15 minutes.
- The method displays high accuracy with a 96.60% overall coincidence rate in clinical samples, indicating its potential for quick and effective diagnostics in healthcare settings.
Bacillus licheniformis B410 Alleviates Inflammation Induced by Lipopolysaccharide and Salmonella by Inhibiting NF-κB and IRF Signaling Pathways in Macrophages.
Probiotics Antimicrob Proteins
December 2024
College of Food Science and Engineering, Yangzhou University, 196 West Huayang Road, Yangzhou, 225127, Jiangsu, China.
Foodborne bacterial enteritis is a common clinical disease, and its incidence has risen globally. To screen for functional Bacillus strains with anti-inflammatory properties, tolerance to acid and bile salts, and antagonism against Salmonella, 22 strains of Bacillus were employed as candidate strains in this study. An inflammatory cell model was established using J774-Dual NF-κB/IRF reporter macrophages to identify anti-inflammatory Bacillus.
View Article and Find Full Text PDFThe role of sodium butyrate in modulating growth, intestinal health, and antimicrobial efficacy in turbot (Scophthalmus maximus L.) fed high soy diets.
Sci Rep
December 2024
Weifang University of Science and Technology, Jinguang Road No. 1299, Weifang City, Shandong Province, China.
Butyrate is one of the most abundant short-chain fatty acids (SCFAs), which are important metabolites of dietary fiber by fermentation of gut commensals, and has been shown to be vital in maintaining host health. The present study mainly investigated how sodium butyrate (NaB) supplementation in the diet with high proportion of soybean meal (SBM) affected turbot. Four experimental diets were formulated: (1) fish meal (FM) based diet (control group), (2) SBM protein replacing 45% FM protein in the diet (high SBM group), (3) 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!