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| http://dx.doi.org/10.1183/23120541.00014-2022 | DOI Listing |
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Genetic Variations on Chromosome 6p21 Are Associated with Asthma Risk and Disease Severity: A Case-Control Study from Pakistan.
Genes (Basel)
December 2024
Center for Applied Molecular Biology (CAMB), University of the Punjab, Lahore 54590, Pakistan.
Background: Genetic factors play a role in asthma severity. However, low- and middle-income countries have minimal contribution to genomic asthma research. The current study investigates the influence of an important genetic asthma region (6p21) on severe asthma in a cohort of asthmatics in Pakistan.
View Article and Find Full Text PDFBackground therapy in severe asthma on monoclonal antibody treatment in real life.
Respir Med
January 2025
S.C. Pneumologia, ASL2 Savonese, Savona, Italy. Electronic address:
Background: Global Initiative for Asthma (GINA) recently recommends clinicians to reduce inhaled corticosteroid doses in patients with severe asthma who respond positively to monoclonal antibodies (MAbs).
Objective: As we operated this reduction even before the document, we analysed our cohort of subjects on treatment with a MAbs for at least 24 months.
Methods: Data stored in our electronic archive and at the 6-month follow-up (FU) were registered and patients' adherence to asthma therapy was derived by electronic pharmacy claim database.
Uncontrolled asthma is Associated with Increased Visceral Adipose Tissue, Decreased Bone Mineral Content, and Reduced Exercise Capacity.
J Asthma Allergy
December 2024
Respiratory Medicine, University Hospital of Liège, Liège, Belgium.
Introduction: Physical inactivity due to shortness of breath is common among patients with uncontrolled asthma. We evaluated the body mass composition and exercise capacity of patients with poorly controlled asthma, despite maximal inhalation therapy.
Methods: We recruited 56 patients from the Asthma Clinic of the University Hospital of Liège between September 2020 and December 2023, and 14 healthy subjects.
[Annual research progress in chronic obstructive pulmonary disease 2024].
Zhonghua Jie He He Hu Xi Za Zhi
January 2025
National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Hetao Institute of Guangzhou National Laboratory, Shenzhen518000, China.
Article Synopsis
- COPD is a growing global health issue, with recent advancements in early detection and personalized treatment, highlighting the importance of monitoring early-stage disease for better prognosis.
- Research has identified critical areas in the lungs as initial sites of damage, and specific biomarkers may help track different disease progression patterns.
- New treatment strategies, including triple inhalation therapy and innovative medications, show promise in managing symptoms and improving patient outcomes in COPD, with ongoing research aimed at understanding disease variability.
Treatment patterns for chronic obstructive pulmonary disease under the tiered medical system.
Sci Rep
January 2025
Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.
China has implemented the "tiered medical services" policy since 2015, while there is a paucity of data evaluating the the current status of chronic obstructive pulmonary disease (COPD) management under the system. Characteristics and treatments from 11,905 COPD patients in 88 hospitals across different tiers in China were included and analyzed. We assessed the statistical significance of differences by one way analysis of variance (ANOVA) for continuous variables and with the chi-squared test for categorical variables.
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