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Crystalloid fluids and delayed graft function in kidney transplant: A cohort study. | LitMetric

AI Article Synopsis

  • - Normal saline is commonly used during kidney transplants but has high chloride levels that can lead to metabolic acidosis; this raises questions about whether electrolyte-balanced solutions might be better.
  • - A study analyzed 138 patients after kidney transplant for seven days, comparing outcomes based on the type and volume of fluids administered and looking at factors linked to delayed graft function (DGF).
  • - The study found that DGF occurred in 8.7% of patients and was mostly affected by surgical factors like cold ischemia time, while the fluid type did not significantly change the DGF rates, even though normal saline led to more acidosis.

Article Abstract

Background: Normal saline is commonly used in the perioperative kidney transplant period; its high chloride content can cause hyperchloremic metabolic acidosis giving a possible advantage to balanced electrolyte solutions due to their lower chloride content. The evidence regarding the best practices in fluid management during kidney transplantation and its effect on the incidence of delayed graft function (DGF) is still limited.

Materials And Methods: One hundred thirty-eight patients were included and followed up for seven days after surgery. Administered crystalloid type and volume were compared among patients with and without DGF, along with additional patient and surgical variables. To investigate whether intraoperative fluid type/amount influence DGF, patients were categorized into three groups: those who received mainly (>50%) lactated Ringer's solution, normal saline, or plasmaLyte. A logistic regression analysis was used to define variables independently correlated with DGF, and odds ratios (OR) with a 95% confidence interval (CI) were reported.

Results: The incidence of DGF was 8.7%. Cold ischemia time independently increased the odds of DGF (OR = 1.006 (95% CI: 1.002-1.011) while fluid type (saline versus PlasmaLyte OR = 5.28, 95% CI: 0.76-36.88) or amount (OR = 1.00, 95% CI: 1.00-1.01) did not significantly modify the odds of DGF. Central venous pressure, systolic blood pressure, and mean arterial pressure were higher in the non-DGF group, but this was not statistically significant ( > 0.05). Significant intraoperative acidosis developed in patients who received normal saline compared to those in PlasmaLyte and lactated Ringer's groups; however, acid-base balance and electrolytes did not vary significantly between the DGF and non-DGF groups.

Conclusion: DGF was primarily influenced by surgical factors such as cold ischemia time, whereas intraoperative fluid type or amount did not affect DGF incidence.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846252PMC
http://dx.doi.org/10.4103/sja.sja_334_21DOI Listing

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