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Molecular Targeting of Ischemic Stroke: The Promise of Naïve and Engineered Extracellular Vesicles.
Pharmaceutics
November 2024
Laboratory of Stem Cells and Tissue Regeneration, Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Ischemic stroke (IS) remains a leading cause of mortality and long-term disability worldwide, with limited therapeutic options available. Despite the success of early interventions, such as tissue-type plasminogen activator administration and mechanical thrombectomy, many patients continue to experience persistent neurological deficits. The pathophysiology of IS is multifaceted, encompassing excitotoxicity, oxidative and nitrosative stress, inflammation, and blood-brain barrier disruption, all of which contribute to neural cell death, further complicating the treatment of IS.
View Article and Find Full Text PDFGenetic Analyses of Flower, Fruit, and Stem Traits of Intergeneric Hybrids Between 'Honghuagqinglong' and 'Heilong' Pitayas.
Plants (Basel)
December 2024
Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China), Ministry of Agriculture and Rural Affairs, College of Horticulture, South China Agricultural University, Guangzhou 510642, China.
Pitaya is renowned for its delicious taste, high nutritional value, and economic as well as ornamental appeal. Breeding new pitaya varieties can boost economic returns by appealing to consumers with diverse morphological traits. However, the genetic basis underlying key traits in intergeneric hybrids of pitaya has yet to be fully understood.
View Article and Find Full Text PDFSelective Scandium Elution from DEHPA-Impregnated Ion-Exchange Resin After Metal Loading from Acidic Chloride Solutions.
Materials (Basel)
December 2024
Laboratory of Metallurgy, School of Mining and Metallurgical Engineering, National Technical University of Athens, Iroon Polytechniou 9 Str., Zografou Campus, 15773 Athens, Greece.
This paper investigates the elution behavior of scandium from DEHPA (Di-(2-ethylhexyl) phosphoric acid)-impregnated resins that proceed with metal loading from acidic chloride solutions. DEHPA resins stem from their recognized selectivity for Sc extraction from acidic solutions. This study focuses on the elution process after ion-exchange extraction and examines various elution systems to achieve selective Sc recovery.
View Article and Find Full Text PDFTRAPPopathies: Severe Multisystem Disorders Caused by Variants in Genes of the Transport Protein Particle (TRAPP) Complexes.
Int J Mol Sci
December 2024
Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
The TRAPP (TRAnsport Protein Particle) protein complex is a multi-subunit complex involved in vesicular transport between intracellular compartments. The TRAPP complex plays an important role in endoplasmic reticulum-to-Golgi and Golgi-to-plasma membrane transport, as well as autophagy. TRAPP complexes comprise a core complex, TRAPPI, and the association of peripheral protein subunits to make two complexes, known as TRAPPII and TRAPPIII, which act as Guanine Nucleotide Exchange Factors (GEFs) of Rab11 and Rab1, respectively.
View Article and Find Full Text PDFSubsidence and Clinical Impact of Obesity in Short-Stem Total Hip Arthroplasty Using a Collarless, Triple-Tapered, Cementless Stem.
J Clin Med
December 2024
Department of Orthopedic Surgery, Ordensklinikum Linz Barmherzige Schwestern, Vinzenzgruppe Center of Orthopedic Excellence, Teaching Hospital of the Paracelsus Medical University, 5020 Salzburg, Austria.
Short-stem total hip arthroplasty (THA) has gained popularity due to its bone-sparing technique, but its outcomes in patients with obesity remain uncertain. The aim of this study was to investigate the impact of obesity on postoperative subsidence and clinical outcomes after short-stem THA. A retrospective cohort study with a minimum follow-up of 24 months was conducted on 163 patients who underwent short-stem THA with a collarless, triple-tapered, cementless stem achieving fixation in the metaphyseal region.
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