When addictive substances are used excessively and a person continues to use them despite the fact this causes problems, this is called substance use disorder. Despite the large scale of the problem, it occurs largely invisibly. However, it has many negative consequences for physical and psychological health, the surroundings (including family, friends, work) and society. Genetic and environmental factors play a role in the origin and continuation of substance use disorders. In many cases, these disorders affect oral health, personal care and treatability. Oral healthcare professionals can play an important role in identifying substance use disorders, in encouraging those with problematic substance use to seek professional help and as an essential step in treatment and recovery.
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http://dx.doi.org/10.5177/ntvt.2022.03.22003 | DOI Listing |
Acute pancreatitis (AP) is a life-threatening condition, with a higher mortality rate in men than women and in which estrogens might play a protective role. This study aimed to investigate sex-dependent differences in a mouse model of caerulein-induced AP. Thirty-six C57BL/6J mice (19 females and 17 males) were treated intraperitoneally with phosphate-buffered saline or caerulein, and sacrificed 12 hours, 2 days, or 7 days after the last injection.
View Article and Find Full Text PDFBiol Cell
January 2025
CRBM (Centre de Recherche en Biologie cellulaire de Montpellier), BIOLuM, University of Montpellier, CNRS UMR 5237, Montpellier, France.
Flotillin 1 and 2 are highly conserved and homologous members of the stomatin, prohibitin, flotillin, HflK/C (SPFH) family. These ubiquitous proteins assemble into hetero-oligomers at the cytoplasmic membrane in sphingolipid-enriched domains. Flotillins play crucial roles in various cellular processes, likely by concentrating sphingosine.
View Article and Find Full Text PDFGastro Hep Adv
September 2024
European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK.
Cureus
December 2024
College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Pediatric dental health is critically impacted by enamel demineralization and early-stage caries, with remineralization therapies playing a vital role in preventing progression. This systematic review evaluates the effectiveness of various delivery methods for remineralization agents in pediatric patients aged 3-15 years, focusing on varnishes, gels, foams, and sprays. Studies were included if they were randomized controlled trials (RCTs), cohort studies, or case-control studies involving pediatric patients with early-stage caries or enamel demineralization, while studies with non-pediatric populations, unrelated treatments, or significant methodological flaws were excluded.
View Article and Find Full Text PDFFront Plant Sci
January 2025
National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University/Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University, Chongqing, China.
Introduction: Citrus tristeza virus (CTV) is a threat to the citrus production and causes severe economic losses to the citrus industry. Ethylene response factors (ERFs) play important roles in plant growth and stress responses. Although ERF genes have been widely studied in model plants, little is known about their role in biological stress responses in fruit trees, such as citrus.
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